Evidence map›Paper›PMID 39252998›Full record

ArticleBrain communications2024

Dynamic balance and gait impairments in Parkinson's disease: novel cholinergic patterns.

Nicolaas I Bohnen, Uros Marusic, Stiven Roytman, Rebecca Paalanen, Fotini Michalakis, Taylor Brown, Peter J H Scott, Giulia Carli, Roger L Albin, Prabesh Kanel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain communications, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Topography of Regional Cerebral GABAThe European journal of neuroscience · 2026
    Article
  3. Is levodopa induced freezing of gait a paradox or an expected phenomenon?: a clinico-pathophysiological hypothesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Nicolaas I BohnenDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105-9755, USA.ORCID https://orcid.org/0000-0003-0352-6414
Uros MarusicInstitute for Kinesiology Research, Science and Research Centre Koper, 6000 Koper, Slovenia, EU.
Stiven RoytmanDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105-9755, USA.
Rebecca PaalanenDepartment of Neurology, University of Michigan, Ann Arbor, MI 48105-9755, USA.
Fotini MichalakisDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105-9755, USA.
Taylor BrownDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105-9755, USA.ORCID https://orcid.org/0009-0004-6421-1007
Peter J H ScottDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105-9755, USA.
Giulia CarliDepartment of Neurology, University of Michigan, Ann Arbor, MI 48105-9755, USA.
Roger L AlbinDepartment of Neurology, University of Michigan, Ann Arbor, MI 48105-9755, USA.
Prabesh KanelDepartment of Radiology, University of Michigan, Ann Arbor, MI 48105-9755, USA.

Funding

Tomography and Data AnalysisP01NS015655 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FREY, KIRK A. · 1985 to 2012
$13.0M
Udall Catalyst Research Project: Retrosplenial Cholinergic and Attentional-Motor Integration DysfunctionP50NS123067 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AHMED, OMAR JAMIL · 2021 to 2025
$11.6M
Public Outreach and Education CoreP50NS091856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DAUER, WILLIAM T. · 2014 to 2019
$10.1M
Central cholinergic presbyvestibulopathy network changes and imbalance in Parkinson's disease and older personsR01AG073100 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2021 to 2025
$3.0M
Hyposmia, Cholinergic Denervation and Incipient Cognitive Decline in PDR01NS070856 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOHNEN, NICOLAAS IDA · 2010 to 2014
$1.9M
Amyloidopathy, cholinopathy, dopamine responsiveness and freezing of gait in PDI01RX001631 · VA · VETERANS HEALTH ADMINISTRATION · PI BOHNEN, NICOLAAS IDA · 2016 to 2020
–
NIA NIH HHS R01 AG073100NINDS NIH HHS P01 NS015655NINDS NIH HHS P50 NS091856NINDS NIH HHS P50 NS123067NINDS NIH HHS R01 NS070856RRD VA I01 RX001631
6 · The paper itself

Abstract

The cholinergic system has been implicated in postural deficits, in particular falls, in Parkinson's disease (PD). Falls and freezing of gait typically occur during dynamic and challenging balance and gait conditions, such as when initiating gait, experiencing postural perturbations, or making turns. However, the precise cholinergic neural substrate underlying dynamic postural and gait changes remains poorly understood. The aim of this study was to investigate whether brain vesicular acetylcholine transporter binding, as measured with [

Indexed as

cholinergicdynamic balanceParkinson’s diseasePET

Identifiers

PMID39252998
PMCPMC11382145

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.