Evidence map›Paper›PMID 39252959›Full record

ArticleiScience2024

Epitranscriptomic reader YTHDF2 regulates SEK1(

Emir Malovic, Alyssa Ealy, Cameron Miller, Ahyoung Jang, Phillip J Hsu, Souvarish Sarkar, Dharmin Rokad, Cody Goeser, Aleah Kristen Hartman, Allen Zhu and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. The mCells · 2025
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors.

Emir MalovicParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Alyssa EalyIsakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.
Cameron MillerIsakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.
Ahyoung JangIsakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.
Phillip J HsuDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Souvarish SarkarParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Dharmin RokadParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Cody GoeserParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Aleah Kristen HartmanParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Allen ZhuDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Bharathi PalanisamyParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Gary ZenitskyIsakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.
Huajun JinIsakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.
Vellareddy AnantharamIsakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.
Arthi KanthasamyParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.
Chuan HeDepartment of Chemistry, University of Chicago, Chicago, IL, USA.
Anumantha G KanthasamyParkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
NIEHS NIH HHS P30 ES027792
6 · The paper itself

Abstract

As the most abundant glial cells in the central nervous system (CNS), astrocytes dynamically respond to neurotoxic stress, however, the key molecular regulators controlling the inflammatory status of these sentinels during neurotoxic stress are many and complex. Herein, we demonstrate that the m6A epitranscriptomic mRNA modification tightly regulates the pro-inflammatory functions of astrocytes. Specifically, the astrocytic neurotoxic stressor, manganese (Mn), downregulated the m6A reader YTHDF2 in human and mouse astrocyte cultures and in the mouse brain. Functionally, YTHDF2 knockdown augmented, while its overexpression dampened, the neurotoxic stress-induced proinflammatory response, suggesting YTHDF2 serves as a key upstream regulator of inflammatory responses in astrocytes. Mechanistically, YTHDF2 RIP-sequencing identified

Indexed as

Cell biologyMolecular mechanism of gene regulationMolecular networkNeurotoxicologyTranscriptomics

Identifiers

PMID39252959
PMCPMC11382029

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.