Evidence map›Paper›PMID 39252912›Full record

ArticlemedRxiv : the preprint server for health sciences2024

Biological Insights from Schizophrenia-associated Loci in Ancestral Populations.

Tim B Bigdeli, Chris Chatzinakos, Jaroslav Bendl, Peter B Barr, Sanan Venkatesh, Bryan R Gorman, Tereza Clarence, Giulio Genovese, Conrad O Iyegbe, Roseann E Peterson and 37 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

47 authors.

Tim B BigdeliVA New York Harbor Healthcare System, Brooklyn, NY.ORCID 0000-0003-2215-5946
Chris ChatzinakosDepartment of Psychiatry and Behavioral Sciences and SUNY Downstate Health Sciences University, Brooklyn, NY.
Jaroslav BendlCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.
Peter B BarrVA New York Harbor Healthcare System, Brooklyn, NY.
Sanan VenkateshCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.
Bryan R GormanMassachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain, MA.
Tereza ClarenceCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.
Giulio GenoveseStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA.
Conrad O IyegbeDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, NY.
Roseann E PetersonVA New York Harbor Healthcare System, Brooklyn, NY.
Sergios-Orestis KolokotronisInstitute for Genomics in Health (IGH), SUNY Downstate Health Sciences University, Brooklyn, NY.
David BursteinCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.
Jacquelyn L MeyersDepartment of Psychiatry and Behavioral Sciences and SUNY Downstate Health Sciences University, Brooklyn, NY.
Yuli LiClinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT.
Nallakkandi RajeevanClinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT.
Frederick SaywardClinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT.
Kei-Hoi CheungClinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT.
Project Among African-Americans to Explore Risks for Schizophrenia (PAARTNERS)
Consortium on the Genomics of Schizophrenia (COGS)
Genomic Psychiatry Cohort (GPC) Investigators
Lynn E DeLisiDepartment of Psychiatry, Cambridge Health Alliance, Cambridge, MA.
Thomas R KostenMichael E. DeBakey VA Medical Center, Houston, TX.
Hongyu ZhaoClinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT.
Eric AchtyesWestern Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, MI.
Peter BuckleyUniversity of Tennessee Health Science Center in Memphis, TN.
Dolores MalaspinaDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, NY.
Douglas LehrerDepartment of Psychiatry, Wright State University, Dayton, OH.
Mark H RapaportHuntsman Mental Health Institute, Department of Psychiatry, University of Utah, Salt Lake City, UT.
David L BraffDepartment of Psychiatry, University of California, San Diego, CA.
Michele T PatoDepartment of Psychiatry, Robert Wood Johnson Medical School, New Brunswick, NJ.
Ayman H FanousDepartment of Psychiatry, University of Arizona College of Medicine-Phoenix, Phoenix, AZ.
Carlos N PatoDepartment of Psychiatry, Robert Wood Johnson Medical School, New Brunswick, NJ.
PsychAD Consortium
Cooperative Studies Program (CSP) #572
Million Veteran Program (MVP)
Grant D HuangOffice of Research and Development, Veterans Health Administration, Washington, DC.
Sumitra MuralidharOffice of Research and Development, Veterans Health Administration, Washington, DC.
J Michael GazianoMassachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain, MA.
Saiju PyarajanMassachusetts Area Veterans Epidemiology, Research, and Information Center (MAVERIC), Jamaica Plain, MA.
Kiran GirdharCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.
Donghoon LeeCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.
Gabriel E HoffmanCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.
Mihaela AslanClinical Epidemiology Research Center (CERC), VA Connecticut Healthcare System, West Haven, CT.
John F FullardCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.
Georgios VoloudakisCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.
Philip D HarveyBruce W. Carter Miami Veterans Affairs (VA) Medical Center, Miami, FL.
Panos RoussosCenter for Disease Neurogenomics, Icahn School of Medicine at Mount Sinai, NY.ORCID 0000-0002-4640-6239

Funding

African Ancestry Genomic Psychiatry CohortR01MH104964 · NIMH · SUNY DOWNSTATE MEDICAL CENTER · PI BIGDELI, TIM BERNARD, FANOUS, AYMAN H · 2015 to 2024
$16.7M
Genomic Psychiatry CohortR01MH085548 · NIMH · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PATO, CARLOS N, PATO, MICHELE T · 2008 to 2012
$16.3M
Understanding the molecular mechanisms that contribute to neuropsychiatric symptoms in Alzheimer DiseaseR01AG067025 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FINKBEINER, STEVEN M, HAROUTUNIAN, VAHRAM · 2019 to 2023
$11.8M
MOLECULAR GENETICS OF SCHIZOPHRENIAR01MH059571 · NIMH · UNIVERSITY OF CHICAGO · PI GEJMAN, PABLO V. · 1999 to 2007
$8.0M
The BrainCellQTL consortium: QTL mapping in the human brain at the single cell levelU24AG087563 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Panagiotis Roussos · 2024 to 2026
$7.2M
The Genetics of Endophenotypes and SchizophreniaR01MH065571 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI BRAFF, DAVID L. · 2003 to 2013
$7.0M
The 3D genome in transcriptional regulation across the postnatal life span, with implications for schizophrenia and bipolar disorderU01MH116442 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AKBARIAN, SCHAHRAM, DRACHEVA, STELLA · 2018 to 2022
$5.9M
Multiethnic genomic epigenomic and transcriptomic fine-mapping and functional validation analysis of schizophrenia and bipolar disorder risk lociR01MH125246 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ROUSSOS, PANAGIOTIS · 2021 to 2025
$5.0M
A Genome-Wide Association Study of SchizophreniaU01MH079469 · NIMH · NORTHSHORE UNIVERSITY HEALTHSYSTEM · PI GEJMAN, PABLO V. · 2007 to 2009
$4.4M
The Genetics of Endophenotypes and SchizophreniaR01MH065578 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GUR, RAQUEL E · 2003 to 2013
$4.2M
The Genetics of Endophenotypes and SchizophreniaR01MH065554 · NIMH · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SIEVER, LARRY J · 2003 to 2013
$4.1M
Genetics of Endophenotypes and SchizophreniaR01MH065558 · NIMH · UNIVERSITY OF WASHINGTON · PI TSUANG, DEBBY WEN · 2003 to 2013
$3.7M
BLRD VA I01 BX004189NIA NIH HHS R01 AG067025NIA NIH HHS R01 AG078657NIA NIH HHS U24 AG087563NIMH NIH HHS K08 MH122911NIMH NIH HHS R01 MH059565NIMH NIH HHS R01 MH059566NIMH NIH HHS R01 MH059571NIMH NIH HHS R01 MH059586NIMH NIH HHS R01 MH059587NIMH NIH HHS R01 MH059588NIMH NIH HHS R01 MH060870NIMH NIH HHS R01 MH060879NIMH NIH HHS R01 MH061675NIMH NIH HHS R01 MH065554NIMH NIH HHS R01 MH065558NIMH NIH HHS R01 MH065562NIMH NIH HHS R01 MH065571NIMH NIH HHS R01 MH065578NIMH NIH HHS R01 MH065588NIMH NIH HHS R01 MH065707NIMH NIH HHS R01 MH067257NIMH NIH HHS R01 MH081800NIMH NIH HHS R01 MH085548NIMH NIH HHS R01 MH086135NIMH NIH HHS R01 MH094320NIMH NIH HHS R01 MH104964NIMH NIH HHS R01 MH125246NIMH NIH HHS U01 MH046276NIMH NIH HHS U01 MH046289NIMH NIH HHS U01 MH046318NIMH NIH HHS U01 MH079469NIMH NIH HHS U01 MH079470NIMH NIH HHS U01 MH116442
6 · The paper itself

Abstract

Large-scale genome-wide association studies of schizophrenia have uncovered hundreds of associated loci but with extremely limited representation of African diaspora populations. We surveyed electronic health records of 200,000 individuals of African ancestry in the Million Veteran and All of Us Research Programs, and, coupled with genotype-level data from four case-control studies, realized a combined sample size of 13,012 affected and 54,266 unaffected persons. Three genome-wide significant signals - near

Identifiers

PMID39252912
PMCPMC11383513

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.