Evidence map›Paper›PMID 39252842›Full record

ArticlePractical laboratory medicine2024

Accidental bufotoxin intoxication: Arenobufagin identification by liquid chromatography coupled to mass spectrometry.

Alessandro Bonari, Mauro Leucio Mattei, Giovanni Cappelli, Francesca Romano, Nicoletta Cini, Francesca Luceri, Donato Squillaci, Stefano Dugheri, Alessandra Fanelli, Nicola Mucci

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Practical laboratory medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alessandro BonariGeneral Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Mauro Leucio MatteiGeneral Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Giovanni CappelliDepartment of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy.
Francesca RomanoGeneral Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Nicoletta CiniGeneral Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Francesca LuceriGeneral Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Donato SquillaciDepartment of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy.
Stefano DugheriDepartment of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy.
Alessandra FanelliGeneral Laboratory, Azienda Ospedaliero-Universitaria Careggi, Florence, Italy.
Nicola MucciDepartment of Experimental and Clinical Medicine, University of Florence, 50121, Florence, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSince ancient times, poisoning, even serious poisoning, has been known to occur during nature walks. Intentional or unintentional ingestion of toxins of animal origin is one of the possible causes of poisoning. Bufadienolide poisoning is a critical case. This is because of its high potency and its ability to cross the blood-brain barrier. Due to the rarity of these poisonings in humans in Central Europe, their identification is often difficult. The following is a case report of a poisoning by toad eggs in an Italina child, that presented vertigo, fussiness and sleepiness. A method of toxin identification using the prince of pharmacotoxicology, liquid chromatography (LC) coupled with tandem mass spectrometry (MS/MS), and an innovative reasoning were used. This method can be applied to other poisoning cases.

Indexed as

BufotoxinLiquid chromatographyMass spectrometryPharmacotoxicology

Identifiers

PMID39252842
PMCPMC11381761

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.