Evidence map›Paper›PMID 39252691›Full record

ArticleInternational journal of pharmaceutics: X2024

EVA implants for controlled drug delivery to the inner ear.

Y Bedulho das Lages, N Milanino, J Verin, J F Willart, F Danede, C Vincent, P Bawuah, J A Zeitler, F Siepmann, J Siepmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutics: X, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Y Bedulho das LagesUniv. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
N MilaninoUniv. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
J VerinUniv. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
J F WillartUniv. Lille, UMR CNRS 8207, UMET, F-59000 Lille, France.
F DanedeUniv. Lille, UMR CNRS 8207, UMET, F-59000 Lille, France.
C VincentUniv. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
P BawuahUniv. Cambridge, Department of Chemical Engineering and Biotechnology, Cambridge CB3 0AS, UK.
J A ZeitlerUniv. Cambridge, Department of Chemical Engineering and Biotechnology, Cambridge CB3 0AS, UK.
F SiepmannUniv. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.
J SiepmannUniv. Lille, Inserm, CHU Lille, U1008, F-59000 Lille, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the potential of poly(ethylene vinyl acetate) (EVA) copolymers as matrix formers in miniaturised implants, allowing to achieve controlled drug delivery into the inner ear. Due to the blood-cochlea barrier, it is impossible to reliably deliver a drug to this tiny and highly sensitive organ in clinical practice. To overcome this bottleneck, different EVA implants were prepared by hot melt extrusion, altering the vinyl acetate content and implant diameter. Dexamethasone was incorporated as a drug with anti-inflammatory and anti-fibrotic activity. Its release was measured into artificial perilymph, and the systems were thoroughly characterised before and after exposure to the medium by optical and scanning electron microscopy, SEM-EDX analysis, DSC, X-ray powder diffraction, X-ray microtomography and texture analysis. Notably, the resulting drug release rates were much higher than from

Indexed as

Controlled releaseDexamethasoneHot melt extrusionInner earPoly(ethylene vinyl acetate)

Identifiers

PMID39252691
PMCPMC11381462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.