ArticleCritical care (London, England)2024
Impact of the timing of invasive mechanical ventilation in patients with sepsis: a multicenter cohort study.
Article in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Effects of Esketamine Versus Remifentanil on Hemodynamics and Prognosis in Patients with Septic Shock Receiving Invasive Mechanical Ventilation: A Randomized Controlled Trial.Drug design, development and therapy · 2025Trial
- Clinical efficacy and metabolomics profiling of dachaihu decoction for patients with septic liver injury: a randomized controlled trial.Frontiers in pharmacology · 2025Trial
- Construction of an associative model for prolonged intensive care unit stay in sepsis patients combined with myocardial injury.Clinics (Sao Paulo, Brazil) · 2026Article
- Prognostic Value of 72-h Reassessment Using SOFA Score, C-Reactive Protein, and Lactate in a 72-h Landmark Cohort of Intensive Care Patients with Gram-Negative Sepsis.Medicina (Kaunas, Lithuania) · 2026Article
- Respiratory mechanics and patient-ventilator interaction dataset from the ICU.Scientific data · 2026Article
- Determinants of caregiver burden among family caregivers of post-intensive care syndrome patients at 2 weeks post-discharge: a cross-sectional study.BMC nursing · 2026Article
- Prognostic determinants of mortality and clinical outcomes in sepsis: a retrospective cohort study.BMC infectious diseases · 2026Article
- Impact of the updated SOFA-2 score on sepsis diagnosis and prognosis: a retrospective multicenter cohort study.Critical care (London, England) · 2026Observational
- Personalized sepsis mortality prediction: An interpretable machine learning nomogram.Clinics (Sao Paulo, Brazil) · 2026Article
- Effect modification by chronic obstructive pulmonary disease, anion gap, and serum creatinine on the association between invasive mechanical ventilation and 28-day mortality in intensive care unit sepsis patients: a retrospective cohort study.Frontiers in medicine · 2026Article
- Survival Time and Determinants of Mortality Among Children Receiving Mechanical Ventilation in Pediatric Intensive Care Units at Selected Hospitals in Kigali, Rwanda - A Retrospective Follow-up Study.Pediatric health, medicine and therapeutics · 2026Article
- Clinical significance of controlling nutritional status score in predicting ICU admission, prolonged hospitalization, and in-hospital mortality in emergency sepsis: a single-center retrospective study.Frontiers in nutrition · 2026Article
- Machine learning-driven sedation-analgesia optimization in mechanically ventilated sepsis patients: a retrospective MIMIC-IV analysis.Frontiers in pharmacology · 2026Article
- Electroacupuncture for the prevention of acute gastrointestinal injury in patients with sepsis undergoing mechanical ventilation (EAGISM): a protocol for an open-label randomized controlled trial.Frontiers in medicine · 2026Article
- Impact of Endotracheal Intubation Timing on Clinical Outcomes in Patients with Severe Pneumonia: A Single-Center Retrospective Cohort Study.Infection and drug resistance · 2026Article
- Platinum-doped emodin carbon dots mitigate sepsis-induced lung injury by targeting the gut-lung axis.Journal of nanobiotechnology · 2025Article
- Does hypoxemia aggravate sepsis-associated acute kidney injury? Integrated clinical and experimental evidence.Intensive care medicine experimental · 2025Article
- From Resuscitation to Rehabilitation: The Post-Intensive Care Syndrome Continuum in Sepsis Care.Journal of clinical medicine · 2025Review
- Association between nutritional risk scores and timing of endotracheal intubation in COVID-19-associated acute respiratory distress syndrome: a single-center cohort study in South Korea.Acute and critical care · 2025Article
- The Impact of Age on In-Hospital Mortality in Patients with Sepsis: Findings from a Nationwide Study.Journal of clinical medicine · 2025Article
Corrections and comments
- Commented on by
- Commented on by
Authors and funding
6 authors.
Funding
Abstract
backgroundThe potential adverse effects associated with invasive mechanical ventilation (MV) can lead to delayed decisions on starting MV. We aimed to explore the association between the timing of MV and the clinical outcomes in patients with sepsis ventilated in intensive care unit (ICU).
methodsWe analyzed data of adult patients with sepsis between September 2019 and December 2021. Data was collected through the Korean Sepsis Alliance from 20 hospitals in Korea. Patients who were admitted to ICU and received MV were included in the study. Patients were divided into 'early MV' and 'delayed MV' groups based on whether they were on MV on the first day of ICU admission or later. Propensity score matching was applied, and patients in the two groups were compared on a 1:1 ratio to overcome bias between the groups. Outcomes including ICU mortality, hospital mortality, length of hospital and ICU stay, and organ failure at ICU discharge were compared.
resultsOut of 2440 patients on MV during ICU stay, 2119 'early MV' and 321 'delayed MV' cases were analyzed. The propensity score matching identified 295 patients in each group with similar baseline characteristics. ICU mortality was lower in 'early MV' group than 'delayed MV' group (36.3% vs. 46.4%; odds ratio, 0.66; 95% confidence interval, 0.47-0.93; p = 0.015). 'Early MV' group had lower in-hospital mortality, shorter ICU stay, and required tracheostomy less frequently than 'delayed MV' group. Multivariable logistic regression model identified 'early MV' as associated with lower ICU mortality (odds ratio, 0.38; 95% confidence interval, 0.29-0.50; p < 0.001).
conclusionIn patients with sepsis ventilated in ICU, earlier start (first day of ICU admission) of MV may be associated with lower mortality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.