Evidence map›Paper›PMID 39252037›Full record

ArticleBMC endocrine disorders2024

Adrenal insufficiency and the use of mineralocorticoid treatment in male patients with adrenoleukodystrophy; a retrospective analysis of an institutional database.

Kidmealem L Zekarias, Michael Salim, Katelyn M Tessier, Angela Radulescu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC endocrine disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kidmealem L ZekariasDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, 420 Delaware St SE, MMC 101, Minneapolis, MN, 55455, USA. kzekaria@umn.edu.
Michael SalimDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, 420 Delaware St SE, MMC 101, Minneapolis, MN, 55455, USA.
Katelyn M TessierBiostatistics Core, Masonic Cancer Center, University of Minnesota, Minneapolis, USA.
Angela RadulescuDepartment of Medicine, Division of Diabetes, Endocrinology and Metabolism, University of Minnesota, 420 Delaware St SE, MMC 101, Minneapolis, MN, 55455, USA.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
NCATS NIH HHS UM1 TR004405
6 · The paper itself

Abstract

introductionAdrenoleukodystrophy (ALD) patients exhibit three primary clinical phenotypes: primary adrenal insufficiency, adrenomyeloneuropathy, and cerebral demyelination due to the accumulation of saturated very long-chain fatty acids in the adrenal cortex and central nervous system white matter and axons. We investigated the diagnosis of adrenal insufficiency (AI) and the use of mineralocorticoid treatment in male ALD patients.

methodsA retrospective chart review of electronic medical records was conducted for all ALD patients at a single institution between January 1, 2011, and December 6, 2021.

resultsAmong the 437 ALD patients, 82% were male and 18% were female. Of the male ALD patients, 60% (213 out of 358) had a diagnosis of AI, and 39% (84 out of 213) of those with AI were prescribed mineralocorticoid replacement therapy.

conclusionAI is highly prevalent among ALD patients, with approximately 40% of those with a diagnosis of AI undergoing mineralocorticoid replacement therapy. Further research is warranted to delineate the characteristics of patients predisposed to developing mineralocorticoid deficiency within the context of ALD and AI.

Indexed as

Adrenal InsufficiencyAdrenoleukodystrophyMineralocorticoidsAdolescentAdultAgedAged, 80 and overAnti-Inflammatory AgentsChildChild, PreschoolFludrocortisoneGlucocorticoidsHumansInfantMaleMiddle AgedAnti-Inflammatory AgentsFludrocortisoneGlucocorticoidsMineralocorticoidsAdrenal insufficiencyAdrenoleukodystrophyMineralocorticoid deficiencyNeurodegenerative disorder

Identifiers

PMID39252037
PMCPMC11382501

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.