ArticleBMC pulmonary medicine2024
The relationship between lung CT features and serum cryptococcal antigen titers in localized pulmonary cryptococcosis patients.
Article in BMC pulmonary medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Pulmonary cryptococcosis in routine care: the clinical-radiologic spectrum and transparent evidence-tier reporting (confirmed versus presumed) among patients with no recorded immunocompromising conditions.Journal of medical microbiology · 2026Observational
- Pulmonary cryptococcosis with cavitation in an immunocompetent child: a case report and literature review.Frontiers in pediatrics · 2026Article
- Postpartum pulmonary cryptococcosis combined with pulmonary embolism: a case report.BMC pulmonary medicine · 2025Article
- Lateral flow assay as radiological prognosis factor of pulmonary cryptococcosis: a single center retrospective study in China.Frontiers in cellular and infection microbiology · 2024Article
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11 authors.
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Abstract
backgroundTo explore the associations of computed tomography (CT) image features with the serum cryptococcal antigen (CrAg) titers measured by the lateral flow assay (LFA) in localized pulmonary cryptococcosis patients.
methodsA retrospective analysis of patients with pathologically confirmed pulmonary cryptococcosis admitted to the First Affiliated Hospital of Xiamen University from January 2016 to December 2022 was performed. Clinical data, CT results, serum CrAg-LFA test results, and follow-up data were collected and analyzed.
resultsA total of 107 patients with localized pulmonary cryptococcosis were included, of which 31 had a single lesion in chest CT and the other 76 had multiple lesions. The positivity rate was (94.74% vs 64.52%) and titers of serum CrAg-LFA (1.77 ± 0.87 vs 0.91 ± 0.98) in the multiple lesion group were higher than those in the single lesion group, respectively. Multivariate linear regression analysis showed that the serum CrAg titers were positively associated with the number of lesions (β, 0.08; 95% CI, 0.05 to 0.12) and the lesion size (β, 0.40; 95% CI, 0.31 to 0.50) after adjusting other covariates. The serum CrAg-LFA titers of 60 pulmonary cryptococcosis patients showed a decreasing trend with the reduction in pulmonary lesion size after effective therapy.
conclusionIn pulmonary cryptococcosis patients, the number and size of lung lesions are positively correlated with the titers of the serum CrAg-LFA test. The CrAg-LFA test could be a useful tool for the diagnosis, severity assessment, and therapeutic monitoring of localized pulmonary cryptococcosis patients.
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