Evidence map›Paper›PMID 39251931›Full record

ArticleBMC infectious diseases2024

Increased plasma AACT level as an indicator of poor prognosis in patients hospitalised with community-acquired pneumonia: a multicentre prospective cohort study.

Lili Zhao, Wen Xi, Ying Shang, Wenjun Gao, Wenjie Bian, Xi Chen, Jianbo Xue, Yu Xu, Pihua Gong, Shuming Guo and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Lili Zhao *Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Beijing, 100044, China.
Wen Xi *Department of Respiratory and Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Beijing, 100044, China.
Ying ShangDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Beijing, 100044, China.
Wenjun GaoDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Beijing, 100044, China.
Wenjie BianDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Beijing, 100044, China.
Xi ChenDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Beijing, 100044, China.
Jianbo XueDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Beijing, 100044, China.
Yu XuDepartment of Respiratory and Critical Care Medicine, Beijing Jishuitan Hospital, No. 31 Xinjiekou East Street, Beijing, 100035, China.
Pihua GongDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Beijing, 100044, China. gardenia1978@163.com.
Shuming GuoLinfen Clinical Medicine Research Center, Linfen Central Hospital, No. 17, Jiefang West Road, Linfen, Shanxi, 041000, China. kyzx@linfench.com.
Zhancheng GaoDepartment of Respiratory and Critical Care Medicine, Peking University People's Hospital, No. 11, Xizhimen South Street, Beijing, 100044, China. zcgao@bjmu.edu.cn.

Funding

Chinese Science and Technology Key Project 2017ZX10103004-006
6 · The paper itself

Abstract

BACKGROUND AND

objectiveCommunity-acquired pneumonia (CAP) is a common respiratory disease that frequently requires hospitalisation, and is a significant cause of death worldwide. This study aimed to evaluate the usefulness of alpha-1-antichymotrypsin (AACT) as a diagnostic and prognostic biomarker of CAP.

methodsWe conducted a multicentre prospective cohort study in patients hospitalised with CAP. Plasma AACT levels were measured using a quantitative enzyme-linked immunosorbent assay. Receiver-operating characteristic (ROC) curves and Cox proportional hazards regression were used to assess the association between plasma AACT levels and CAP diagnosis and prognosis.

resultsA total of 274 patients with CAP were enrolled in the study. AACT levels were elevated in patients with CAP, especially those with severe CAP and non-survivors. The area under the curve (AUC) of AACT and CRP for diagnosing CAP was 0.755 and 0.843. Cox regression showed that CURB-65 and AACT levels were independent predictors of 30-day mortality. ROC curves showed that plasma AACT levels had the highest accuracy for predicting acute respiratory distress syndrome (ARDS), with an AUC of 0.862. Combining AACT with Pneumonia Severity Index and CURB-65 significantly improved their predictive accuracy for predicting 30-day mortality.

conclusionPlasma AACT levels are elevated in patients with CAP, but plasma AACT level is inferior to the C-reactive protein level for diagnosing CAP. The AACT level can reliably predict the occurrence of ARDS and 30-day mortality in patients with CAP.

Indexed as

BiomarkersCommunity-Acquired InfectionsHospitalizationPneumoniaROC CurveAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedPrognosisProspective StudiesSeverity of Illness IndexBiomarkersAlpha-1-antichymotrypsinCommunity-acquired pneumoniaDiagnosisMortalityPrognosisProspective cohort study

Identifiers

PMID39251931
PMCPMC11384707

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