SynthesisBMC gastroenterology2024
Incidence and risk factors for colorectal cancer in Africa: a systematic review and meta-analysis.
Synthesis in BMC gastroenterology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Global, regional, and national burden of early-onset and late-onset colorectal cancer, 1990-2021: a comparative analysis for the Global Burden of Disease Study 2021.Future science OA · 2026Article
- Early-onset colorectal cancer in patients under 30: a case series from Tanzania highlighting an emerging epidemiological shift.Journal of surgical case reports · 2026Article
- Colorectal Cancer Risk Factors in Adults in Nigeria.JAMA network open · 2026Article
- Emerging trends in the global burden of colorectal cancer.Nature reviews. Clinical oncology · 2026Review
- Pediatric Colorectal Cancer in Africa: A Multicenter Study on Epidemiology, Management, and Outcomes Between 2000 and 2023.JGH open : an open access journal of gastroenterology and hepatology · 2026Article
- Sigmoid diverticulitis mimicking colorectal cancer: A case report.Radiology case reports · 2026Article
- Colorectal cancer incidence, survival analysis and predictions (Monastir, Tunisia: 2002-2030).PloS one · 2026Article
- Understanding colorectal cancer-related stigma and its impact on cancer survivors in South-West Nigeria: a qualitative study of patients, caregivers, and healthcare professionals.Journal of cancer survivorship : research and practice · 2025Article
- Addressing gastrointestinal disorders in rural Ethiopia: Success of a weekend outreach colonoscopy service.World journal of gastrointestinal endoscopy · 2025Article
- Trend analysis and epidemiological forecasting of colorectal Cancer mortality among reproductive-age women in sub-Saharan Africa.Preventive medicine reports · 2025Article
- Colorectal Cancer Risk and Protective Factors Among People of African Descent: A Systematic Review and Meta-Analysis.Cureus · 2025Review
- Rising Incidence and Mortality of Colorectal Cancer in Young African Adults: Need for a Better Care Plan.Cureus · 2025Review
- Global burden and trends analysis of common cancers attributable to dietary risks from 1990 to 2021 and projection to 2050: a secondary analysis for the global burden of disease study 2021.Frontiers in nutrition · 2025Article
- Associations of the Healthy Beverage Index and the risk of colorectal cancer: a case-control study.Frontiers in nutrition · 2025Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionColorectal cancer (CRC) is the second leading cause of cancer-related death worldwide. There is a significant burden of mortality from colorectal cancer in Africa. Due to the heterogeneity of dietary and lifestyle practices throughout Africa, our work sought to define risk factors for the development of CRC in the African continent.
methodsWe systematically searched PubMed, Embase, Global Health, CINAHL, Cochrane CENTRAL, and African Index Medicus for studies written in English, examining the incidence and risk factors of CRC in Africa. A systematic analysis was done to compare different risk factors in constituent studies. A meta-analysis random effects model was fitted to estimate the pooled incidence of CRC.
resultsOf 2471 studies screened, 26 were included for the quantitative analysis; 20 in the incidence analysis, and six in the risk factor analysis. The overall ASIR per 100,000 person-years of CRC for males and females was 7.51 and 6.22, respectively. The highest incidence rates were observed between 2012 and 2021. Risk factors for CRC in Africa include tobacco smoking, and consumption of red meat, butter, and alcohol. Protective factors included, regular consumption of fruits and regular physical activity.
conclusionThe incidence of CRC in Africa is higher than that suggested by previous studies. Our study shows that nonmodifiable and modifiable factors contribute to CRC in Africa. High-quality studies conducted on generalizable populations that examine risk factors in a comprehensive fashion are required to inform primary and secondary prevention initiatives for CRC in Africa.
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