Evidence map›Paper›PMID 39251914›Full record

ArticleMolecular medicine (Cambridge, Mass.)2024

Protective effect of ghrelin in oxidative stress-induced age-related macular degeneration in vitro and in vivo.

Jie Bai, Yanqing Wang, Yanze Li, Yan Liu, Shan Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular medicine (Cambridge, Mass.), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. MiR-21-5p promotes RPE cell necroptosis by targeting Peli1 in a rat model of AMD.In vitro cellular & developmental biology. Animal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jie BaiDepartment of Ophthalmology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, Zhejiang, P. R. China. 8020234@zju.edu.cn.
Yanqing WangDepartment of Ophthalmology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, Zhejiang, P. R. China.
Yanze LiDepartment of Ophthalmology, the Fourth Affiliated Hospital of School of Medicine, and International School of Medicine, International Institutes of Medicine, Zhejiang University, Yiwu, 322000, Zhejiang, P. R. China.
Yan LiuDepartment of Ophthalmology and Otorhinolaryngology, Yiwu Second People's Hospital, Yiwu, 322000, Zhejiang, P. R. China.
Shan WangDepartment of Oral Pathology, School of Stomatology, Hainan Medical University, Haikou, 571199, P. R. China. birchtree20032003@126.com.ORCID 0000-0003-1921-1644

Funding

Zhejiang Province's New Talent in the Medical R21008
6 · The paper itself

Abstract

Oxidative damage to human retinal pigment epithelial (RPE) cells is the main cause of age-related macular degeneration (AMD), in our previous work, we showed that ghrelin has an antioxidative effect on human lens epithelium (HLE) cells, however, the studies of using ghrelin in treating the degenerative diseases of the retina have rarely been reported. In this article, we assessed the effect of ghrelin on preventing oxidative stress induced by hydrogen peroxide (H

Indexed as

ApoptosisDisease Models, AnimalGhrelinHydrogen PeroxideMacular DegenerationOxidative StressRetinal Pigment EpitheliumAnimalsAntioxidantsCell LineHumansIodatesMaleMiceMice, Inbred C57BLAntioxidantsGhrelinHydrogen PeroxideIodatessodium iodateAge-related macular degenerationGhrelinOxidative stressVitro and vivo

Identifiers

PMID39251914
PMCPMC11384690

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.