Evidence map›Paper›PMID 39251895›Full record

ArticleJournal of neurodevelopmental disorders2024

Project GIVE: using a virtual genetics service platform to reduce health inequities and improve access to genomic care in an underserved region of Texas.

Blake Vuocolo, Roberta Sierra, Daniel Brooks, Christopher Holder, Lauren Urbanski, Keila Rodriguez, Jose David Gamez, Surya Narayan Mulukutla, Ana Hernandez, Alberto Allegre and 15 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurodevelopmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07102966 (MAGNET), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07102966 narecruitingnot on this mapstarted 2025, after this paper: background citation

MAGNET: Making Genomics Accessible For Newborns In Texas

TypeinterventionalSponsorBaylor College of MedicineRan2025 to 2029Enrolled410ConditionsRare DiseasesArmsRapid whole genome sequencing
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Blake VuocoloDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R806, Houston, TX, 77030, USA.
Roberta SierraDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R806, Houston, TX, 77030, USA.
Daniel BrooksDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R806, Houston, TX, 77030, USA.
Christopher HolderDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R806, Houston, TX, 77030, USA.
Lauren UrbanskiDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R806, Houston, TX, 77030, USA.
Keila RodriguezPrimary and Community Care, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Jose David GamezDHR Health Diabetes and Endocrinology Institute, Edinburg, TX, 78539, USA.
Surya Narayan MulukutlaDHR Health Diabetes and Endocrinology Institute, Edinburg, TX, 78539, USA.
Ana HernandezPrimary and Community Care, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Alberto AllegrePrimary and Community Care, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Humberto HidalgoPrimary and Community Care, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Sarah RodriguezDepartment of Otolaryngology, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Sandy MagallanDepartment of Otolaryngology, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Jeremy GibsonPrimary and Community Care, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Juan Carlos BerniniVannie E. Cook Jr. Children's Cancer and Hematology Clinic, McAllen, TX, 78503, USA.
Melanie WatsonMilestones Therapeutic Associates, McAllen, TX, 78501, USA.
Robert NelsonPrimary and Community Care, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Lizbeth Mellin-SanchezDepartment of Pediatrics, University of Florida, Jacksonville, FL, 32207, USA.
Nancy GarciaRio Grande Valley, Easterseals, TX, 78505, USA.
Lori BerryPrimary and Community Care, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Hongzheng DaiDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R806, Houston, TX, 77030, USA.
Claudia Soler-AlfonsoDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R806, Houston, TX, 77030, USA.
Kent CarterPrimary and Community Care, University of Texas Rio Grande Valley, Harlingen, TX, 78550, USA.
Brendan LeeDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R806, Houston, TX, 77030, USA.
Seema R LalaniDepartment of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, R806, Houston, TX, 77030, USA. seemal@bcm.edu.ORCID 0000-0003-0707-657X

Funding

Preclinical and Clincial OutcomesP50HD103555 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI Sandesh Chakravarthy Sreenath Nagamani, David Loren Nelson · 2020 to 2026
$9.9M
Virtual Platforms for Genetics Evaluation in the Medically UnderservedUH3TR004047 · NCATS · BAYLOR COLLEGE OF MEDICINE · PI Seema R Lalani · 2024 to 2026
$1.4M
Virtual Platforms for Genetics Evaluation in the Medically UnderservedUG3TR004047 · NCATS · BAYLOR COLLEGE OF MEDICINE · PI LALANI, SEEMA R · 2022 to 2023
$619k
NCATS NIH HHS 5UG3TR004047NCATS NIH HHS UG3 TR004047NCATS NIH HHS UH3 TR004047NICHD NIH HHS P50 HD103555
6 · The paper itself

Abstract

backgroundThe utilization of genomic information to improve health outcomes is progressively becoming more common in clinical practice. Nonetheless, disparities persist in accessing genetic services among ethnic minorities, individuals with low socioeconomic status, and other vulnerable populations. The Rio Grande Valley (RGV) at the Texas-Mexico border is predominantly Hispanic/Latino with a high poverty rate and very limited access to genetic services. Funded by the National Center for Advancing Translational Sciences, Project GIVE (Genetic Inclusion by Virtual Evaluation) was launched in 2022 to reduce the time to diagnosis and increase provider knowledge of genomics in this region, with the goal of improving pediatric health outcomes. We describe our experience of establishing a virtual pediatric genomic service in this region to expeditiously identify, recruit, and evaluate pediatric patients with undiagnosed diseases.

methodsWe have utilized an innovative electronic health record (EHR) agnostic virtual telehealth and educational platform called Consultagene to receive referrals from healthcare providers in the RGV. Using this portal, genetic services, including virtual evaluation and genome sequencing (GS), are being delivered to children with rare diseases. The study has also integrated effective methods to involve and educate community providers through in-person meetings and Continuing Professional Education (CPE) events.

resultsThe recruitment efforts have proven highly successful with the utilization of Consultagene in this medically underserved region. The project's ongoing engagement efforts with local healthcare providers have resulted in progressively more referrals to the study over time, thus improving inclusion and access to genomic care in the RGV. Additionally, the curated CPE content has been well received by healthcare providers in the region.

conclusionsProject GIVE study has allowed advanced genetic evaluation and delivery of GS through the virtual Consultagene portal, effectively circumventing the recognized socioeconomic and logistical barriers to accessing genetic services within this border community.

Indexed as

Health Services AccessibilityMedically Underserved AreaTelemedicineAdolescentChildElectronic Health RecordsFemaleGenetic ServicesGenomicsHealthcare DisparitiesHealth InequitiesHumansMaleTexasConsultageneGenome sequencingMedically underserved populationVirtual access to genomics

Identifiers

PMID39251895
PMCPMC11382520

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.