Evidence map›Paper›PMID 39251667›Full record

ArticleScientific reports2024

Lipidomics profiling and circulating triglyceride concentrations in sub-Saharan African individuals.

Amy R Bentley, Ayo P Doumatey, Jie Zhou, Lin Lei, Karlijn A C Meeks, Elisabeth F Heuston, Charles N Rotimi, Adebowale A Adeyemo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Building 12A Room 1025, Bethesda, MD, 20892-5635, USA. amy.bentley@nih.gov.
Ayo P DoumateyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Building 12A Room 1025, Bethesda, MD, 20892-5635, USA.
Jie ZhouCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Building 12A Room 1025, Bethesda, MD, 20892-5635, USA.
Lin LeiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Building 12A Room 1025, Bethesda, MD, 20892-5635, USA.
Karlijn A C MeeksCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Building 12A Room 1025, Bethesda, MD, 20892-5635, USA.
Elisabeth F HeustonCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Building 12A Room 1025, Bethesda, MD, 20892-5635, USA.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Building 12A Room 1025, Bethesda, MD, 20892-5635, USA.
Adebowale A AdeyemoCenter for Research on Genomics and Global Health, National Human Genome Research Institute, National Institutes of Health, 12 South Drive, Building 12A Room 1025, Bethesda, MD, 20892-5635, USA. adeyemoa@mail.nih.gov.

Funding

Genetic epidemiology of complex diseasesZ01HG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2008 to 2008
$1.7M
Unravelling the Role of Epigenetics and Cytokines in Type 2 Diabetes among African-ancestry PopulationsK99DK131018 · NIDDK · NATIONAL HUMAN GENOME RESEARCH INST · PI MEEKS, KARLIJN ANNA CATHARINA · 2023 to 2023
$0k
MINORITY INTERNATIONAL RESEARCH TRAINING GRANTT37TW000041 · FIC · HOWARD UNIVERSITY · PI ADAMS-CAMPBELL, LUCILE L · 1993 to 1998
–
FIC NIH HHS T37 TW000041Intramural NIH HHS Z01 HG200362NIDDK NIH HHS K99 DK131018NIDDK NIH HHS Z01HG200362NIH HHS DK131018NIH Office of the Director Z01HG200362Office of Research on Minority Health, National Institutes of Health 3T37TW00041-03S2
6 · The paper itself

Abstract

Elevated triglycerides (TG) are a risk factor for cardiometabolic disorders. There are limited data on lipidomics profiles associated with serum triglycerides concentrations, although these could advance our understanding of the mechanisms underlying these associations. We conducted a lipidomics study of 308 Nigerians with replication in 199 Kenyans. Regression models were used to assess the association of TG with 480 lipid metabolites. Association and mediation analyses were conducted to determine the relationship among TG, metabolites, and several cardiometabolic traits. Ninety-nine metabolites were significantly associated with TG, and 91% of these associations replicated. Overrepresentation analysis identified enrichment of diacylglycerols, monoacylglycerols, diacylglycerophosphoethanolamines, monoacylglycerophosphocholines, ceramide phosphocholines, and diacylglycerophosphocholines. TG-cardiometabolic trait associations were largely mediated by TG-associated metabolites. Associations with type 2 diabetes, waist circumference, body mass index, total cholesterol, and low-density lipoprotein cholesterol concentration were independently mediated by metabolites in multiple subpathways. This lipidomics study in sub-Saharan Africans demonstrated that TG is associated with several non-TG lipids classes, including phosphatidylethanolamines, phosphatidylcholines, lysophospholipids, and plasmalogens, some of which may mediate the effect of TG as a risk factor for cardiometabolic disorders. The study identifies metabolites that are more proximal to cardiometabolic traits, which may be useful for understanding the underlying biology as well as differences in TG-trait associations across ancestries.

Indexed as

LipidomicsTriglyceridesAdultAfrica South of the SaharaBody Mass IndexDiabetes Mellitus, Type 2FemaleHumansMaleMiddle AgedWaist CircumferenceTriglycerides

Identifiers

PMID39251667
PMCPMC11385232

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.