ArticleDocumenta ophthalmologica. Advances in ophthalmology2024
Age-dependencies of the electroretinogram in healthy subjects.
Article in Documenta ophthalmologica. Advances in ophthalmology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- The oscillatory response of the electroretinogram and neuronal adaptation.Acta ophthalmologica · 2026Review
- Functional and structural retinal alterations in Alzheimer's disease: insights from photopic negative response (PhNR) and OCT-based analysis.Documenta ophthalmologica. Advances in ophthalmology · 2026Article
- Synthetic electroretinogram signal generation using a conditional generative adversarial network.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Electroretinography With the RM Electrode: Normative Reference Ranges, Variation With Age, and Comparison With the Burian-Allen Electrode.Translational vision science & technology · 2025Article
- ISCEV standard full-field ERG reference limits from 407 healthy subjects, derived from transference and validation of reference data between electrode types and centres.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Remodeling the light-adapted electroretinogram using a bayesian statistical approach.BMC research notes · 2025Article
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Authors and funding
7 authors.
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Abstract
objectiveThe purpose of this study was to evaluate the age-dependency of amplitudes and implicit times in the electroretinograms (ERGs) of healthy individuals and provide clinicians and researchers with a reference for a variety of stimulus paradigms. DESIGN AND
methodsFull-field electroretinography was conducted on 73 healthy participants aged 14-73 using an extended ISCEV standard protocol that included an additional 9 Hz flicker stimulus for assessing rod function and special paradigms for isolated On-Off and S-cone responses. Correlation coefficients and best-fit regression models for each parameter's age-dependency were calculated.
resultsDark-adapted ERGs, in particular, displayed notable age-related alterations. The attenuation and delay of the b-wave with higher age were most significant in the dark-adapted, rod-driven 0.001 cd s/m
conclusionThe results suggest that rod and cone function decline at different rates with age, with rods being generally more affected by aging. Nonetheless, response amplitudes displayed a wide variability across the whole sample.
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