Evidence map›Paper›PMID 39251427›Full record

ArticleAnalytical and bioanalytical chemistry2024

Diagnosis of viral infectious diseases through sensitive detection of human serum antibodies using a modified label-free electrochemical biosensor.

Tatianny de Araujo Andrade, Iare Soares Ribeiro, Tiago Almeida Silva, Leyllanne Katharinne Araujo de Souza, Wendell Karlos Tomazelli Coltro, Lysandro Pinto Borges, Deise Maria Rego Rodrigues Silva, Paulo de Tarso Garcia, Jemmyson Romário de Jesus

Abstract read
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In one paragraph

Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tatianny de Araujo AndradeFaculty of Chemistry, Universidade Federal do Sul e Sudeste do Pará, Marabá, Pará, 68507-670, Brazil.
Iare Soares RibeiroResearch Laboratory in Bionanomaterials, LPbio, Department of Chemistry, Federal University of Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil.
Tiago Almeida SilvaDepartment of Chemistry, Federal University of Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil.
Leyllanne Katharinne Araujo de SouzaInstituto de Química, Universidade Federal de Goiás, Goiânia, 74690-900, Brazil.
Wendell Karlos Tomazelli ColtroInstituto de Química, Universidade Federal de Goiás, Goiânia, 74690-900, Brazil.
Lysandro Pinto BorgesDepartment of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, 49100-000, Brazil.
Deise Maria Rego Rodrigues SilvaDepartment of Pharmacy, Federal University of Sergipe, São Cristóvão, Sergipe, 49100-000, Brazil.
Paulo de Tarso GarciaFaculty of Chemistry, Universidade Federal do Sul e Sudeste do Pará, Marabá, Pará, 68507-670, Brazil. paulo.garcia@ufj.edu.br.
Jemmyson Romário de JesusResearch Laboratory in Bionanomaterials, LPbio, Department of Chemistry, Federal University of Viçosa, Viçosa, Minas Gerais, 36570-900, Brazil. jemmyson.jesus@ufv.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 05828/2022-5Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 88887.805573/2023-00Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ-01786-22Fundação de Amparo à Pesquisa do Estado de Minas Gerais APQ- 05429-23Fundação de Amparo à Pesquisa do Estado de Minas Gerais RED-00144-22
6 · The paper itself

Abstract

Rapid virus identification is crucial for preventing outbreaks. The COVID-19 pandemic has highlighted the critical nature of rapid virus detection. Here, we designed a label-free electrochemical biosensor modified with gold nanoparticles (AuNPs) to detect IgG antibodies from human serum, enabling rapid point-of-care diagnostics. AuNPs were synthesized and characterized. A multivariate optimization was carried out to determine the optimal condition for functionalizing AuNPs with anti-IgG. Subsequently, using a glassy carbon electrode (GCE), a modified AuNPs/GCE electrochemical biosensor was developed for IgG detection. The results indicated that AuNPs displayed a spherical morphology with a size distribution of 19.54 nm. Additionally, the zeta potential was recorded at -7.84 mV. Central composite design (CCD) analysis determined the optimal conditions for functionalizing AuNPs to be an anti-IgG concentration of 320 µg mL

Indexed as

Biosensing TechniquesElectrochemical TechniquesGoldImmunoglobulin GLimit of DetectionMetal NanoparticlesSARS-CoV-2Antibodies, ViralCOVID-19ElectrodesHumansAntibodies, ViralGoldImmunoglobulin GBiosensorGold nanoparticlesIgGLabel-free

Identifiers

PMID39251427

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.