Evidence map›Paper›PMID 39251117›Full record

ArticleMitochondrion2024

Mitochondrial acyl carrier protein, Acp1, required for iron-sulfur cluster assembly in mitochondria and cytoplasm in Saccharomyces cerevisiae.

Ashutosh K Pandey, Heeyong Yoon, Jayashree Pain, Andrew Dancis, Debkumar Pain

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mitochondrion, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ashutosh K PandeyDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07103, United States.
Heeyong YoonDepartment of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
Jayashree PainDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07103, United States.
Andrew DancisDepartment of Medicine, Division of Hematology-Oncology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, United States.
Debkumar PainDepartment of Pharmacology, Physiology and Neuroscience, New Jersey Medical School, Rutgers University, Newark, NJ 07103, United States. Electronic address: painde@njms.rutgers.edu.

Funding

Mitochondria-cytoplasm interactions for cytosolic Fe-S cluster assemblyR01GM107542 · NIGMS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI DANCIS, ANDREW B., PAIN, DEBKUMAR · 2014 to 2023
$4.5M
NIGMS NIH HHS R01 GM107542NIGMS NIH HHS R01 GM107542-06S1
6 · The paper itself

Abstract

Mitochondria perform vital biosynthetic processes, including fatty acid synthesis and iron-sulfur (FeS) cluster biogenesis. In Saccharomyces cerevisiae mitochondria, the acyl carrier protein Acp1 participates in type II fatty acid synthesis, requiring a 4-phosphopantetheine (PP) prosthetic group. Acp1 also interacts with the mitochondrial FeS cluster assembly complex that contains the cysteine desulfurase Nfs1. Here we investigated the role of Acp1 in FeS cluster biogenesis in mitochondria and cytoplasm. In the Acp1-depleted (Acp1↓) cells, biogenesis of mitochondrial FeS proteins was impaired, likely due to greatly reduced Nfs1 protein and/or its persulfide-forming activity. Formation of cytoplasmic FeS proteins was also deficient, suggesting a disruption in generating the (Fe-S)

Indexed as

Acyl Carrier ProteinCytoplasmIronIron-Sulfur ProteinsMitochondriaSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsMitochondrial ProteinsSulfurtransferasesAcyl Carrier ProteinIronIron-Sulfur ProteinsMitochondrial ProteinsNFS1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSulfurtransferasesCysteine desulfuraseCytoplasmFeS cluster assemblyIron-sulfur intermediateMitochondria

Identifiers

PMID39251117
PMCPMC13344127

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.