SynthesisJMIR mental health2024
Empathic Conversational Agent Platform Designs and Their Evaluation in the Context of Mental Health: Systematic Review.
Synthesis in JMIR mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The Emerging Roles of AI in Self-Directed Stress Management: Systematic Review.Journal of medical Internet research · 2026Pooled it
- Concerns of Using Large Language Models in Health Care Research and Practice: Umbrella Review.Journal of medical Internet research · 2026Pooled it
- Chatbot interventions for improving mental health among people in Asia: a systematic review and meta-analysis of randomised controlled trials.BMJ health & care informatics · 2026Pooled it
- A Patient Simulation Framework for Risk Assessment of Conversational Health Care AI: Development and Evaluation Study.JMIR AI · 2026Article
- Dual-Source Retrieval-Augmented Generation Chatbot for Women's Health (HerCare): Design and Multimethod Evaluation Study.JMIR formative research · 2026Article
- AI-Enabled First-Response Support After Sexual and Gender-Based Violence: A PRISMA-ScR Scoping Review.Healthcare (Basel, Switzerland) · 2026Review
- Behavior Change Content and Implementation of Large Language Model-Driven Conversational Agents in Cardiometabolic Care: Scoping Review.Journal of medical Internet research · 2026Article
- Trust-driven healthy engagement with conversational AI for mental health support in young adults: a mixed methods study.Scientific reports · 2026Article
- Accuracy and empathy of AI-based conversational chatbots in response to temporomandibular dysfunction related queries.PEC innovation · 2026Article
- Article
- Toward clinical integration of generative AI in mental health: personalization, multimodality and inter-entity experience.Frontiers in public health · 2026Article
- Multimodal Sensing-Enabled Large Language Models for Automated Emotional Regulation: A Review of Current Technologies, Opportunities, and Challenges.Sensors (Basel, Switzerland) · 2025Review
- Machine Learning Approach to Identifying Empathy Using the Vocals of Mental Health Helpline Counselors: Algorithm Development and Validation.JMIR formative research · 2025Article
- Repositioning intellectual disability in the ethics of digital mental health technologies.Frontiers in psychiatry · 2025Article
- A theory-driven user-centered design framework for wellness applications targeting young adults: The MiCARE methodology.Digital healthArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe demand for mental health (MH) services in the community continues to exceed supply. At the same time, technological developments make the use of artificial intelligence-empowered conversational agents (CAs) a real possibility to help fill this gap.
objectiveThe objective of this review was to identify existing empathic CA design architectures within the MH care sector and to assess their technical performance in detecting and responding to user emotions in terms of classification accuracy. In addition, the approaches used to evaluate empathic CAs within the MH care sector in terms of their acceptability to users were considered. Finally, this review aimed to identify limitations and future directions for empathic CAs in MH care.
methodsA systematic literature search was conducted across 6 academic databases to identify journal articles and conference proceedings using search terms covering 3 topics: "conversational agents," "mental health," and "empathy." Only studies discussing CA interventions for the MH care domain were eligible for this review, with both textual and vocal characteristics considered as possible data inputs. Quality was assessed using appropriate risk of bias and quality tools.
resultsA total of 19 articles met all inclusion criteria. Most (12/19, 63%) of these empathic CA designs in MH care were machine learning (ML) based, with 26% (5/19) hybrid engines and 11% (2/19) rule-based systems. Among the ML-based CAs, 47% (9/19) used neural networks, with transformer-based architectures being well represented (7/19, 37%). The remaining 16% (3/19) of the ML models were unspecified. Technical assessments of these CAs focused on response accuracies and their ability to recognize, predict, and classify user emotions. While single-engine CAs demonstrated good accuracy, the hybrid engines achieved higher accuracy and provided more nuanced responses. Of the 19 studies, human evaluations were conducted in 16 (84%), with only 5 (26%) focusing directly on the CA's empathic features. All these papers used self-reports for measuring empathy, including single or multiple (scale) ratings or qualitative feedback from in-depth interviews. Only 1 (5%) paper included evaluations by both CA users and experts, adding more value to the process.
conclusionsThe integration of CA design and its evaluation is crucial to produce empathic CAs. Future studies should focus on using a clear definition of empathy and standardized scales for empathy measurement, ideally including expert assessment. In addition, the diversity in measures used for technical assessment and evaluation poses a challenge for comparing CA performances, which future research should also address. However, CAs with good technical and empathic performance are already available to users of MH care services, showing promise for new applications, such as helpline services.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.