Evidence map›Paper›PMID 39250769›Full record

ArticleAJOB empirical bioethics

Deep Brain Stimulation for Childhood Treatment-Resistant Obsessive-Compulsive Disorder: Mental Health Clinician Views on Candidacy Factors.

Ilona Cenolli, Tiffany A Campbell, Natalie Dorfman, Meghan Hurley, Jared N Smith, Kristin Kostick-Quenet, Eric A Storch, Jennifer Blumenthal-Barby, Gabriel Lázaro-Muñoz

Abstract read
In one paragraph

Article in AJOB empirical bioethics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ilona CenolliHarvard Center for Bioethics, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-2859-6358
Tiffany A CampbellHarvard Center for Bioethics, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0002-9350-7446
Natalie DorfmanCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, USA.
Meghan HurleyCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-0418-8691
Jared N SmithCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, USA.
Kristin Kostick-QuenetCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0003-2510-0174
Eric A StorchDepartment of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston, Texas, USA.ORCID 0000-0002-7631-3703
Jennifer Blumenthal-BarbyCenter for Medical Ethics and Health Policy, Baylor College of Medicine, Houston, Texas, USA.
Gabriel Lázaro-MuñozHarvard Center for Bioethics, Harvard Medical School, Boston, Massachusetts, USA.ORCID 0000-0003-1933-9453

Funding

Pediatric Deep Brain Stimulation: Neuroethics and Decision Making: Training SupplementRF1MH121371 · NIMH · BAYLOR COLLEGE OF MEDICINE · PI BLUMENTHAL-BARBY, JENNIFER, LAZARO-MUNOZ, GABRIEL · 2019 to 2020
$1.9M
NIMH NIH HHS RF1 MH121371
6 · The paper itself

Abstract

introductionDeep brain stimulation (DBS) is approved under a humanitarian device exemption to manage treatment-resistant obsessive-compulsive disorder (TR-OCD) in adults. It is possible that DBS may be trialed or used clinically off-label in children and adolescents with TR-OCD in the future. DBS is already used to manage treatment-resistant childhood dystonia. Evidence suggests it is a safe and effective intervention for certain types of dystonia. Important questions remain unanswered about the use of DBS in children and adolescents with TR-OCD, including whether mental health clinicians would refer pediatric patients for DBS, and who would be a good candidate for DBS.

objectivesTo explore mental health clinicians' views on what clinical and psychosocial factors they would consider when determining which children with OCD would be good DBS candidates. MATERIALS AND

methodsIn depth, semi-structured interviews were conducted with

conclusionsClinicians generally saw considering DBS treatment in youth as a last resort and only for very specific cases. DBS referral was predominantly viewed as acceptable for children with severe TR-OCD who have undertaken intensive, appropriate treatment without success, whose OCD has significantly reduced their quality of life, and who exhibit strong motivation to continue treatment given the right environment. Appropriate safeguards, eligibility criteria, and procedures should be discussed and identified before DBS for childhood TR-OCD becomes practice.

Indexed as

Attitude of Health PersonnelDeep Brain StimulationObsessive-Compulsive DisorderPatient SelectionAdolescentAdultChildFemaleHumansMaleQualitative ResearchDBS candidacy factorsDeep brain stimulationmental health cliniciansOCDpediatric patientstreatment-resistance

Identifiers

PMID39250769
PMCPMC11785495

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.