Evidence map›Paper›PMID 39250747›Full record

ArticleNeurology2024

Pearls & Oy-sters: Exquisite Response of Sleep-Related Hypermotor Epilepsy to a Nicotine Patch.

Spencer Nam, Erica L Von Stein, Kimford J Meador, Rebecca J Levy, William Gallentine, Yi Li

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Spencer NamFrom the Department of Neurology and Neurological Sciences, Stanford University, CA.ORCID 0000-0001-8689-6730
Erica L Von SteinFrom the Department of Neurology and Neurological Sciences, Stanford University, CA.
Kimford J MeadorFrom the Department of Neurology and Neurological Sciences, Stanford University, CA.ORCID 0000-0002-7471-882X
Rebecca J LevyFrom the Department of Neurology and Neurological Sciences, Stanford University, CA.ORCID 0000-0003-0393-6835
William GallentineFrom the Department of Neurology and Neurological Sciences, Stanford University, CA.
Yi LiFrom the Department of Neurology and Neurological Sciences, Stanford University, CA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sleep-related hypermotor epilepsy (SHE), previously known as nocturnal frontal lobe epilepsy, is characterized by brief (<2 minutes) seizures with abrupt onset and offset and stereotyped focal or generalized hypermotor events occurring predominantly (but not exclusively) from sleep. Clinically, SHE can be challenging to distinguish from psychogenic nonepileptic events or sleep disorders. Up to 30% of SHE cases are drug-resistant, and SHE represents about 10% of drug-resistant surgical epilepsy cases. Although most cases have an unknown etiology, there is a subset of individuals with pathogenic variants in the subunits of n-acetylcholine receptors (nAChR). Furthermore, some individuals with nAChR variants are responsive to nicotine. We report a case of a 23-year-old man with SHE, but no pathogenic variant on testing, whose seizures were exquisitely responsive to removal and application of a nicotine patch. This suggests an alternative mechanism of nicotine in the suppression of seizures in individuals with SHE.

Indexed as

Tobacco Use Cessation DevicesElectroencephalographyEpilepsy, Frontal LobeHumansMaleNicotineNicotinic AgonistsYoung AdultNicotineNicotinic Agonists

Identifiers

PMID39250747
PMCPMC11385953

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.