Evidence map›Paper›PMID 39250517›Full record

ArticleMagnetic resonance in medicine2025

Optimization of

Neil E Wilson, Mark A Elliott, Ravi Prakash Reddy Nanga, Sophia Swago, Walter R Witschey, Ravinder Reddy

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Quantification of Tryptophan and NADMagnetic resonance in medicine · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Neil E WilsonCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0009-0002-7766-2929
Mark A ElliottCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Ravi Prakash Reddy NangaCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-3644-5656
Sophia SwagoCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0001-8334-4746
Walter R WitscheyCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0003-1669-2120
Ravinder ReddyCenter for Advanced Metabolic Imaging in Precision Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

Funding

High Spatial and Temporal Resolution MRI Mapping of Oxygen Consumption in HumansP41EB029460 · NIBIB · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2021 to 2026
$7.6M
In vivo Mapping of Muscle Specific MetabolismR01AG071725 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Ravinder Reddy · 2022 to 2026
$3.1M
Imaging of glutamatergic system changes in Alzheimer's disease in vivoR01AG063869 · NIA · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 2020 to 2024
$3.0M
Non-invasive imaging of reactive oxygen species in reperfusion injury myocardial infarctionR01HL169378 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI PACO E. BRAVO, Walter R.T. Witschey · 2023 to 2026
$3.0M
Cardiac MR imaging of hemorrhagic reperfusion injury after myocardial infarctionR01HL137984 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI WITSCHEY, WALTER R.T. · 2018 to 2022
$2.8M
LONGITUDINAL ASSOCIATION OF POST-INFARCT LIPOMATOUS METAPLASIA AND MALIGNANT ARRHYTHMIAR01HL171709 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Saman Nazarian, Walter R.T. Witschey · 2024 to 2026
$2.2M
Cardiac 1H MRS assessment of NAD+ after Tetralogy of Fallot repairF31HL158217 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI SWAGO, SOPHIA · 2021 to 2023
$140k
NHLBI NIH HHS F31 HL158217NHLBI NIH HHS F31HL158217NHLBI NIH HHS R01 HL137984NHLBI NIH HHS R01HL137984NHLBI NIH HHS R01 HL169378NHLBI NIH HHS R01HL169378NHLBI NIH HHS R01 HL171709NHLBI NIH HHS R01HL171709NIA NIH HHS R01 AG063869NIA NIH HHS R01AG063869NIA NIH HHS R01 AG071725NIA NIH HHS R01AG071725NIBIB NIH HHS P41 EB029460NIBIB NIH HHS P41EB029460
6 · The paper itself

Abstract

purposeThis goal of this study was to optimize spectrally selective

methodsSpectrally selective excitation was used to avoid magnetization-transfer effects with water, and various sinc pulses were compared with a band-selective, uniform response, pure-phase (E-BURP) pulse. Localization using a single-slice selective pulse was compared with voxel-based localization that used three orthogonal refocusing pulses, and low bandwidth refocusing pulses were used to take advantage of the chemical shift displacement of water. A technique for water sideband removal was added, and a method of coil channel combination for large volumes was introduced.

resultsProposed methods were compared qualitatively with previously reported techniques at 7 T. Sinc pulses resulted in reduced water signal excitation and improved spectral quality, with a symmetric, low bandwidth-time product pulse performing best. Single-slice localization allowed shorter TEs with large volumes, enhancing signal, whereas low-bandwidth slice-selective localization greatly reduced the observed water signal. Gradient cycling helped remove water sidebands, and frequency aligning and pruning individual channels narrowed spectral linewidths. High-quality brain spectra of NAD

conclusionImproved spectral quality with higher downfield signal, shorter TE, lower nuisance signal, reduced artifacts, and narrower peaks was realized at 7 T. These methodological improvements allowed for previously unachievable detection of NAD

Indexed as

BrainNADTryptophanAdultAlgorithmsFemaleHumansMagnetic Resonance ImagingMalePhantoms, ImagingProton Magnetic Resonance SpectroscopyNADTryptophanbraindownfield proton spectroscopylarge volumeNADskeletal muscletryptophan

Identifiers

PMID39250517
PMCPMC11518639

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.