Evidence map›Paper›PMID 39249600›Full record

ArticleMolecular and cellular biochemistry2025

Endothelium Piezo1 deletion alleviates experimental varicose veins by attenuating perivenous inflammation.

Jiani Zhao, Yacheng Xiong, Yu Liu, Jin Ling, Shuai Liu, Wei Wang

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Article in Molecular and cellular biochemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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  6. Open biology · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiani ZhaoDepartment of General and Vascular Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yacheng XiongDepartment of General and Vascular Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Yu LiuDepartment of General and Vascular Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Jin LingDepartment of General and Vascular Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China.
Shuai LiuDepartment of General and Vascular Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China. liushuai@csu.edu.cn.
Wei WangDepartment of General and Vascular Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China. weiwangcsu@csu.edu.cn.

Funding

National Natural Science Foundation of China 81873525Natural Science Foundation of Hunan Province 2021JJ31102
6 · The paper itself

Abstract

Previous large-scale genetic studies have prioritized the causal genes piezo type mechanosensitive ion channel component 1 (PIEZO1) and castor zinc finger 1 (CASZ1) associated with varicose veins (VVs). This study aims to evaluate their roles in both clinical and experimental VVs. In this study, we investigated abundance of PIEZO1 and CASZ1 in both varicose and normal veins from the same patients. Yoda1 (a selective PIEZO1 agonist, 2.6 mg/kg/day) or vehicle was administered intraperitoneally for 3 weeks to evaluate the effect of PIEZO1 activation on experimental VVs. Subsequently, endothelial Piezo1 deletion mice (Piezo1

Indexed as

Endothelium, VascularGene DeletionInflammationIon ChannelsVaricose VeinsAnimalsDisease Models, AnimalFemaleHumansMaleMiceMice, KnockoutIon ChannelsPIEZO1 protein, humanPiezo1 protein, mouseEndothelial cellsInflammationPiezo type mechanosensitive ion channel component 1Varicose veinsVascular biology

Identifiers

PMID39249600

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.