ArticleMolecular biology reports2024
Chrysin downregulates the expression of ADAMTS-4 in foam cells.
Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Adamts4 coordinates the transcriptomic profile of primary rat costal chondrocytes.Stem cells translational medicine · 2026Article
- Exploring the Role of ADAMTS4 Expression in Atherosclerosis.Methods in molecular biology (Clifton, N.J.) · 2026Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundChrysin, a polyphenolic compound, possesses antioxidant and anti-inflammatory properties. In this study, we investigated the effect of chrysin on the expression of A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), a protease enzyme involved in degrading extracellular matrix associated with atherosclerosis. METHODS AND
resultsWe have studied the cell viability by MTT assay and foam cell formation by oil red O staining. The mRNA and protein expression of ADAMTS-4 was studied using quantitative polymerase chain reaction (qPCR) and Western blotting, respectively. Our study showed that chrysin significantly downregulates the expression of ADAMTS-4 in foam cells.
conclusionChrysin's ability to downregulate the expression of ADAMTS-4, a protease involved in degrading the extracellular matrix, bestows upon it a new therapeutic potential for managing atherosclerosis.
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39249599What OpenQuestion holds
Registered trials
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