Strategies for producing probiotic biomass and postbiotics from Akkermansia muciniphila in submerged cultivations incorporating prebiotic sources.

Sheila Montipó, Elisa Bellan Menegussi, Roselei Claudete Fontana, Marli Camassola

Abstract read

In one paragraph

Article in World journal of microbiology & biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Therapeutic properties of plant-derived prebiotics in melanoma.Exploration of targeted anti-tumor therapy · 2025
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sheila MontipóBiotechnology Institute, University of Caxias do Sul, Caxias do Sul, 95070-560, Brazil. smontipo@ucs.br.

Elisa Bellan MenegussiBiotechnology Institute, University of Caxias do Sul, Caxias do Sul, 95070-560, Brazil.

Roselei Claudete FontanaBiotechnology Institute, University of Caxias do Sul, Caxias do Sul, 95070-560, Brazil.

Marli CamassolaBiotechnology Institute, University of Caxias do Sul, Caxias do Sul, 95070-560, Brazil.

Funding

Coordination for the Improvement of Higher Education Personnel 88887.476198/2020-00

6 · The paper itself

Abstract

This research propounds an innovative technology focused on sustainability to increase the biomass yield of Akkermansia muciniphila, the next-generation probiotic, using prebiotic sources to replace or reduce animal mucin levels. A series of experimental design approaches were developed aiming to optimize the growth of Akkermansiamuciniphila by incorporating extracts of green leafy vegetables and edible mushroom into the cultivation media. Experiments using kale extract (KE), Brassica oleracea L., associated with lyophilized mushroom extract (LME) of Pleurotus ostreatus were the most promising, highlighting the assays with 0.376% KE and 0.423% LME or 1.05% KE and 0.5% LME, in which 3.5 × 10

Indexed as

AkkermansiaBiomassCulture MediaPrebioticsProbioticsVerrucomicrobiaBrassicaFatty Acids, VolatilePlant ExtractsPleurotusCulture MediaFatty Acids, VolatilePlant ExtractsPrebioticsBrassica oleracea L.Edible mushroomExperimental designNext-generation probioticShort-chain fatty acids

Identifiers

PMID39249571

DOI10.1016/j.jnutbio.2023.109356

What OpenQuestion holds

Textmetadata

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.