Evidence map›Paper›PMID 39249538›Full record

ArticleEuropean journal of applied physiology2025

Acute exercise-induced inflammatory and thrombotic response in hypertensive patients.

Charalampos I Liakos, Constantina Aggeli, Konstantinos P Toutouzas, Maria I Markou, Gregory P Vyssoulis, Constantinos Tsioufis

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Article in European journal of applied physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Charalampos I LiakosDepartment of Medicine, School of Health Sciences, 1st Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, 114 V. Sofias Avenue, 11527, Athens, Greece. bliakos@med.uoa.gr.ORCID http://orcid.org/0000-0003-1222-3415
Constantina AggeliDepartment of Medicine, School of Health Sciences, 1st Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, 114 V. Sofias Avenue, 11527, Athens, Greece.
Konstantinos P ToutouzasDepartment of Medicine, School of Health Sciences, 1st Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, 114 V. Sofias Avenue, 11527, Athens, Greece.
Maria I Markou1st Internal Medicine Clinic, NIMTS Hospital, 11521, Athens, Greece.
Gregory P VyssoulisDepartment of Medicine, School of Health Sciences, 1st Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, 114 V. Sofias Avenue, 11527, Athens, Greece.
Constantinos TsioufisDepartment of Medicine, School of Health Sciences, 1st Cardiology Clinic, Hippokration General Hospital, National and Kapodistrian University of Athens, 114 V. Sofias Avenue, 11527, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeVigorous physical activity may acutely trigger the onset of an acute coronary syndrome especially in sedentary persons with established cardiovascular risk factors such as arterial hypertension. The rupture of an inflamed coronary plaque and the activation of the coagulation cascade are the main underlying mechanisms. The present study aimed to determine the effect of acute exercise on the inflammatory and thrombotic response in patients with arterial hypertension as compared to normotensive peers.

methodsAfter excluding patients with any inflammatory or/and coronary artery disease, a total of 60 non-treated hypertensive patients and 65 normotensive individuals underwent a maximal treadmill exercise testing. Βlood samples were drawn at rest and immediately after peak exercise. High-sensitivity C-reactive protein (hsCRP), serum amyloid A (SAA), white blood cell (WBC), interleukin-6 (IL-6), and total fibrinogen (TF) levels, as well as plasminogen activator inhibitor-1 (PAI-1) activity, were measured.

resultsAll biomarkers increased with exercise, except PAI-1, which decreased (P < 0.05 for the change between resting and peak exercise for all biomarkers). Αfter adjusting for relevant confounders (duration of exercise, metabolic equivalents, systolic BP, and rate-pressure product achieved at peak exercise), the normotensive group had less marked (P < 0.05) exercise-induced changes than the hypertensive group in hsCRP (7.7 vs. 8.6%), SAA (5.6 vs. 11.9%), WBC (45.0 vs. 51.7%), and PAI-1 (-17.3 vs. -20.1%) and a similar (P = NS) change in IL-6 (23.8 vs. 23.0%) and TF (8.5 vs. 8.5%).

conclusionIn conclusion, the acute exercise-induced inflammatory and thrombotic response seems to be more pronounced in non-treated hypertensive patients than in normotensive controls. Possible clinical implications of this finding merit further examination.

Indexed as

ExerciseHypertensionInflammationThrombosisAgedBiomarkersC-Reactive ProteinFemaleHumansInterleukin-6MaleMiddle AgedPlasminogen Activator Inhibitor 1BiomarkersC-Reactive ProteinInterleukin-6Plasminogen Activator Inhibitor 1Acute-phase responseArterial hypertensionBiomarkersExerciseInflammatory responseThrombotic response

Identifiers

PMID39249538

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.