Evidence map›Paper›PMID 39249170›Full record

ArticleAnnals of biomedical engineering2025

Sonothrombolysis Using Microfluidically Produced Microbubbles in a Murine Model of Deep Vein Thrombosis.

Yanjun Xie, Yi Huang, Hugo C S Stevenson, Li Yin, Kaijie Zhang, Zain Husain Islam, William Aaron Marcum, Campbell Johnston, Nicholas Hoyt, Eric William Kent and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of biomedical engineering, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yanjun XieDepartment of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, VA, 22908, USA.
Yi HuangDepartment of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, VA, 22908, USA.
Hugo C S StevensonDepartment of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, VA, 22908, USA.
Li YinDepartment of Surgery, School of Medicine, University of Virginia, 409 Lane Rd MR4, Charlottesville, VA, 22908, USA.
Kaijie ZhangDepartment of Surgery, School of Medicine, University of Virginia, 409 Lane Rd MR4, Charlottesville, VA, 22908, USA.
Zain Husain IslamDepartment of Surgery, School of Medicine, University of Virginia, 409 Lane Rd MR4, Charlottesville, VA, 22908, USA.
William Aaron MarcumDepartment of Surgery, School of Medicine, University of Virginia, 409 Lane Rd MR4, Charlottesville, VA, 22908, USA.
Campbell JohnstonDepartment of Surgery, School of Medicine, University of Virginia, 409 Lane Rd MR4, Charlottesville, VA, 22908, USA.
Nicholas HoytDepartment of Surgery, School of Medicine, University of Virginia, 409 Lane Rd MR4, Charlottesville, VA, 22908, USA.
Eric William KentDepartment of Surgery, School of Medicine, University of Virginia, 409 Lane Rd MR4, Charlottesville, VA, 22908, USA.
Bowen WangDepartment of Surgery, School of Medicine, University of Virginia, 409 Lane Rd MR4, Charlottesville, VA, 22908, USA.
John A HossackDepartment of Biomedical Engineering, University of Virginia, 415 Lane Road, Charlottesville, VA, 22908, USA. jh7fj@virginia.edu.

Funding

The Role of Amino Acid Starvation Response Kinase GCN2 in Abdominal Aortic AneurysmR01HL162895 · NHLBI · UNIVERSITY OF VIRGINIA · PI Bowen Wang · 2022 to 2026
$2.0M
Accelerated Low Dose Thrombolytic Catheter Directed SonothrombolysisR01HL141752 · NHLBI · UNIVERSITY OF VIRGINIA · PI HOSSACK, JOHN A · 2018 to 2021
$2.0M
VisualSonics Vevo 2100 Small Animal Ultrasound Imaging System and AccessoriesS10RR027333 · NCRR · UNIVERSITY OF VIRGINIA · PI HOSSACK, JOHN A · 2010 to 2010
$482k
NCRR NIH HHS S10 RR027333NHLBI NIH HHS R01 HL141752NHLBI NIH HHS R01 HL162895NIH HHS R01 HL141752NIH HHS R01 HL162895
6 · The paper itself

Abstract

The need for safe and effective methods to manage deep vein thrombosis (DVT), given the risks associated with anticoagulants and thrombolytic agents, motivated research into innovative approaches to resolve blood clots. In response to this challenge, sonothrombolysis is being explored as a technique that combines microbubbles, ultrasound, and thrombolytic agents to facilitate the aggressive dissolution of thrombi. Prior studies have indicated that relatively large microbubbles accelerate the dissolution process, either in an in vitro or an arterial model. However, sonothrombolysis using large microbubbles must be evaluated in venous thromboembolism diseases, where blood flow velocity is not comparable. In this study, the efficacy of sonothrombolysis was validated in a murine model of pre-existing DVT. During therapy, microfluidically produced microbubbles of 18 μm diameter and recombinant tissue plasminogen activator (rt-PA) were administered through a tail vein catheter for 30 min, while ultrasound was applied to the abdominal region of the mice. Three-dimensional ultrasound scans were performed before and after therapy for quantification. The residual volume of the thrombi was 20% in animals post sonothrombolysis versus 52% without therapy (

Indexed as

MicrobubblesThrombolytic TherapyUltrasonic TherapyVenous ThrombosisAnimalsDisease Models, AnimalMiceTissue Plasminogen ActivatorTissue Plasminogen ActivatorDeep vein thrombosisMicrobubbleMicrofluidicsSonothrombolysisUltrasound

Identifiers

PMID39249170
PMCPMC11782319

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.