Evidence map›Paper›PMID 39249145›Full record

ArticleMolecular biology reports2024

Association of MTR and MTRR polymorphisms with recurrent pregnancy loss: a case control study.

Mai M Shaker, Nesma M Elaraby, Taghreed A Shalabi

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In one paragraph

Article in Molecular biology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Mai M ShakerPrenatal Diagnosis and Fetal Medicine Department, Human Genetics and Genome Research Institute, NationalResearch Centre, Cairo, Egypt. maishaker777@gmail.com.
Nesma M ElarabyMedical Molecular Genetics Department, Human Genetics and Genome Research Institute, National ResearchCentre, Cairo, Egypt.
Taghreed A ShalabiPrenatal Diagnosis and Fetal Medicine Department, Human Genetics and Genome Research Institute, NationalResearch Centre, Cairo, Egypt.

Funding

National Research Centre, Egypt 12060180
6 · The paper itself

Abstract

backgroundIn light of several epidemiological studies, the etiology of recurrent pregnancy loss is complex. One of the most frequent causes of women experiencing inexplicable recurrent pregnancy loss is maternal thrombophilia. Hence, the association between genetic polymorphisms causing thrombophilia and recurrent pregnancy loss needs to be explored.

aimIs to study the relation of polymorphisms affecting folate pathway mainly, 5-Methytetrahydrofolate-Homocysteine Methyltransferase (MTR A2756G) and 5-Methytetrahydrofolate-Homocysteine MethyltransferaseReductase (MTRR A66G) with recurrent pregnancy loss.

methodsIt is a case-control study. Four hundred participants were enrolled. Two hundred participants with unexplained recurrent pregnancy loss (case group) and two hundred healthy fertile participants (control group). All participants were screened for (MTR A2756G) and (MTRR A66G). DNA was extracted using salting out method followed by genotyping via Real-time PCR.

resultsMutant homozygous genotype (GG) in MTRR A66G was statistically significantly among RPL group in comparison to controls. (GG vs. AA) had odds ratio and confidence interval of 1.22(1.12-2.23), P = 0.012. (GG) increased the liability 1.2 folds for recurrent pregnancy loss. Mutant homozygous genotype (GG) in MTR A2756G was not correlated with the risk of recurrent pregnancy loss. (GG vs.AA) = (1.13(0.56-2.29)), P = 0.7

conclusionMTRR A66G increases susceptibly for recurrent pregnancy loss among Egyptian women.

Indexed as

5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseAbortion, HabitualFerredoxin-NADP ReductaseGenetic Predisposition to DiseasePolymorphism, Single NucleotideAdultAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenotypeHumansOdds RatioPregnancy5-Methyltetrahydrofolate-Homocysteine S-MethyltransferaseFerredoxin-NADP Reductasemethionine synthase reductaseMTR protein, humanFolatePolymorphismPregnancy loss

Identifiers

PMID39249145

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