Evidence map›Paper›PMID 39248711›Full record

ArticleAging2024

MTA2 knockdown suppresses human osteosarcoma metastasis by inhibiting uPA expression.

Chun Tseng, Chien-Min Chen, Yi-Hsien Hsieh, Chia-Yu Lin, Jian-Wen Chen, Pang-Hsuan Hsiao, Yi-Chin Fong, Pei-Han Wang, Pei-Ni Chen, Renn-Chia Lin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chun TsengGraduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.
Chien-Min ChenDivision of Neurosurgery, Department of Surgery, Changhua Christian Hospital, Changhua, Taiwan.
Yi-Hsien HsiehInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Chia-Yu LinDepartment of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan.
Jian-Wen ChenDepartment of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan.
Pang-Hsuan HsiaoDepartment of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan.
Yi-Chin FongDepartment of Orthopedic Surgery, China Medical University Hospital, Taichung, Taiwan.
Pei-Han WangInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Pei-Ni ChenInstitute of Medicine, Chung Shan Medical University, Taichung, Taiwan.
Renn-Chia LinDepartment of Orthopedics, Chung Shan Medical University Hospital, Taichung, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between metastasis-associated protein 2 (MTA2) overexpression and tumor growth and metastasis has been extensively studied in a variety of tumor cells but not in human osteosarcoma cells. This study aims to elucidate the clinical significance, underlying molecular mechanisms, and biological functions of MTA2 in human osteosarcoma

Indexed as

Bone NeoplasmsCell MovementGene Knockdown TechniquesHistone DeacetylasesOsteosarcomaRepressor ProteinsUrokinase-Type Plasminogen ActivatorAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMaleMAP Kinase Signaling SystemMiceMice, NudeHistone DeacetylasesMTA2 protein, humanRepressor ProteinsUrokinase-Type Plasminogen ActivatorERKmetastasisMTA2osteosarcomauPA

Identifiers

PMID39248711
PMCPMC11424574

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.