Evidence map›Paper›PMID 39248596›Full record

ArticleEnvironmental toxicology2025

Suppression of Hippocampal Neurogenesis and Oligodendrocyte Maturation Similar to Developmental Hypothyroidism by Maternal Exposure of Rats to Ammonium Perchlorate, a Gunpowder Raw Material and Known Environmental Contaminant.

Yuri Sakamaki, Momoka Shobudani, Ryota Ojiro, Shunsuke Ozawa, Qian Tang, Xinyu Zou, Yuri Ebizuka, Ayumi Karasawa, Gye-Hyeong Woo, Toshinori Yoshida and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental toxicology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuri SakamakiLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Momoka ShobudaniLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Ryota OjiroLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.ORCID https://orcid.org/0000-0002-4480-5252
Shunsuke OzawaLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.ORCID https://orcid.org/0000-0003-1102-5871
Qian TangLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Xinyu ZouLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Yuri EbizukaLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Ayumi KarasawaLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.
Gye-Hyeong WooLaboratory of Histopathology, Department of Clinical Laboratory Science, Semyung University, Jecheon, Chungbuk, Republic of Korea.
Toshinori YoshidaLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.ORCID https://orcid.org/0000-0003-2476-7794
Makoto ShibutaniLaboratory of Veterinary Pathology, Division of Animal Life Science, Institute of Agriculture, Tokyo University of Agriculture and Technology, Tokyo, Japan.ORCID https://orcid.org/0000-0003-3417-9697

Funding

Ministry of Health, Labour and Welfare, Japan 22KD1002
6 · The paper itself

Abstract

The environmental contaminant perchlorate raises concern for hypothyroidism-related brain disorders in children. This study investigated the effects of developmental perchlorate exposure on hippocampal neurogenesis and oligodendrocyte (OL) development. Pregnant Sprague-Dawley rats were administered with ammonium perchlorate (AP) in drinking water at concentrations of 0 (control), 300, and 1000 ppm from gestation day 6 until weaning [postnatal day (PND) 21]. On PND 21, offspring displayed decreased serum triiodothyronine and thyroxine concentrations at 1000 ppm and thyroid follicular epithelial cell hyperplasia at ≥300 ppm (accompanying increased proliferation activity at 1000 ppm). Hippocampal neurogenesis indicated suppressed proliferation of neurogenic cells at ≥300 ppm, causing decreases in type-1 neural stem cells (NSCs) and type-2a neural progenitor cells. In addition, an increase of SST

Indexed as

HippocampusHypothyroidismMaternal ExposureNeurogenesisOligodendrogliaPerchloratesPrenatal Exposure Delayed EffectsRats, Sprague-DawleyAnimalsEnvironmental PollutantsFemaleMaleNeural Stem CellsPregnancyQuaternary Ammonium CompoundsRatsammonium perchlorateEnvironmental PollutantsPerchloratesQuaternary Ammonium CompoundsThyroxineammonium perchloratedevelopmental neurotoxicityhippocampal neurogenesishypothyroidismoligodendrogenesis

Identifiers

PMID39248596
PMCPMC11628657

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.