ArticleThe Journal of infectious diseases2024
Shigella and Enterotoxigenic Escherichia coli Have Replaced Rotavirus as Main Causes of Childhood Diarrhea in Rwanda After 10 Years of Rotavirus Vaccination.
Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Protecting Newborns from Multidrug-Resistant Infections: The Emerging Role of Bacteriophages.Viruses · 2026Review
- A compliance assessment tool for household pit latrines and cesspits against RS ISO 24521: evidence from Kigali City.Frontiers in public health · 2026Article
- Epidemiology of selected communicable diseases in Rwanda: a comprehensive analysis of the prevalence of major infectious diseases in Rwanda.International journal of emergency medicine · 2025Review
- Non-Secretor Status Due toMicroorganisms · 2025Article
- Evidence needs and community involvement in policy decisions for vaccine-preventable diarrhoeal infections among children under the age of five years: Stakeholder engagement in Ethiopia, Kenya, and Malawi.PLOS global public health · 2025Article
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Authors and funding
5 authors.
Funding
Abstract
The causes of diarrhea after 10 years of rotavirus vaccination in Rwanda were investigated with real-time polymerase chain reaction in 496 children with diarrhea and 298 without. Rotavirus was detected in 11% of children with diarrhea (odds ratio, 2.48; P = .002). Comparison of population attributable fractions (PAFs) shows that Shigella (PAF, 11%) and enterotoxigenic Escherichia coli producing labile toxin (PAF, 12%) have replaced rotavirus as the main causative agents. The PAF for rotavirus had declined from 41% prevaccination to 6.5% postvaccination, indicating that rotavirus has become one among several similarly important causes of childhood diarrhea in Rwanda. A rotavirus genotype shift to G3P[8] points at the importance of continued genotype surveillance.
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