Evidence map›Paper›PMID 39248268›Full record

ArticleJournal of the American Heart Association2024

Relationship Between Infarct Artery, Myocardial Injury, and Outcomes After Primary Percutaneous Coronary Intervention in ST-Segment-Elevation Myocardial Infarction.

Suzanne de Waha, Manesh R Patel, Holger Thiele, James E Udelson, Christopher B Granger, Ori Ben-Yehuda, Lak Kotinkaduwa, Björn Redfors, Ingo Eitel, Harry P Selker and 2 more

Abstract read
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Triple Antithrombotic Therapy vs Dual Antiplatelet for Prevention of Left Ventricular Thrombus After Anterior Myocardial Infarction: An Updated Meta-Analysis.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Suzanne de WahaHeart Center Leipzig at the University of Leipzig Leipzig Germany.
Manesh R PatelDuke University Medical Center Durham NC.ORCID 0000-0002-2393-0855
Holger ThieleHeart Center Leipzig at the University of Leipzig Leipzig Germany.ORCID 0000-0002-0169-998X
James E UdelsonInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center Boston MA.ORCID 0000-0003-2998-910X
Christopher B GrangerDuke University Medical Center Durham NC.ORCID 0000-0002-0045-3291
Ori Ben-YehudaUniversity of California San Diego San Diego CA.ORCID 0000-0001-9199-1660
Lak KotinkaduwaThe Cardiovascular Research Foundation New York NY.
Björn RedforsThe Cardiovascular Research Foundation New York NY.ORCID 0000-0002-4155-4451
Ingo EitelUniversity Heart Center Lübeck and the German Center for Cardiovascular Research Lübeck Germany.ORCID 0000-0002-6442-246X
Harry P SelkerInstitute for Clinical Research and Health Policy Studies, Tufts Medical Center Boston MA.ORCID 0000-0001-5322-7178
Akiko MaeharaThe Cardiovascular Research Foundation New York NY.ORCID 0000-0002-1910-8447
Gregg W StoneThe Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai New York NY.ORCID 0000-0002-3416-8210

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe extent to which infarct artery impacts the extent of myocardial injury and outcomes in patients with ST-segment-elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention is uncertain. METHODS AND

resultsWe performed a pooled analysis using individual patient data from 7 randomized STEMI trials in which myocardial injury within 30 days after primary percutaneous coronary intervention was assessed in 1774 patients by cardiac magnetic resonance (n=1318) or technetium-99m sestamibi single-photon emission computed tomography (n=456). Clinical follow-up was performed at a median duration of 351 days (interquartile range, 184-368 days). Infarct size and outcomes were assessed in anterior (infarct vessel=left anterior descending) versus nonanterior (non-left anterior descending) STEMI. Median infarct size (percentage left ventricular myocardial mass) was larger in patients with anterior compared with nonanterior STEMI (19.7% [interquartile range, 9.4%-31.7%] versus 12.6% [interquartile range, 5.1%-20.5%];

conclusionsAnterior STEMI was associated with substantially greater myonecrosis after primary percutaneous coronary intervention compared with nonanterior STEMI, contributing in large part to the worse prognosis in patients with anterior infarction.

Indexed as

Anterior Wall Myocardial InfarctionPercutaneous Coronary InterventionST Elevation Myocardial InfarctionTomography, Emission-Computed, Single-PhotonAgedCoronary VesselsFemaleHumansMaleMiddle AgedMyocardiumRandomized Controlled Trials as TopicRisk FactorsTechnetium Tc 99m SestamibiTime FactorsTreatment OutcomeTechnetium Tc 99m Sestamibiinfarct arteryinfarct sizemicrovascular obstructionprognosisST‐segment–elevation myocardial infarction

Identifiers

PMID39248268
PMCPMC11935624

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.