Evidence map›Paper›PMID 39248265›Full record

Trial reportJournal of the American Heart Association2024

Clopidogrel Versus Aspirin as Chronic Maintenance Antiplatelet Monotherapy in Patients After Percutaneous Coronary Intervention With Chronic Kidney Disease: A Post Hoc Analysis of the HOST-EXAM Trial.

Jeehoon Kang, Sang-Hyeon Park, Kyung Woo Park, Bon-Kwon Koo, Huijin Lee, Minju Han, Doyeon Hwang, Han-Mo Yang, In-Ho Chae, Won-Yong Shin and 7 more

Abstract readRandomized Controlled TrialMulticenter StudyComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Jeehoon KangDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.ORCID 0000-0002-9078-2231
Sang-Hyeon ParkDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.ORCID 0000-0001-8453-4146
Kyung Woo ParkDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.ORCID 0000-0003-2432-4432
Bon-Kwon KooDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.ORCID 0000-0002-8188-3348
Huijin LeeDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.ORCID 0009-0004-5930-2705
Minju HanDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.ORCID 0000-0002-0748-287X
Doyeon HwangDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.
Han-Mo YangDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.ORCID 0000-0002-1548-2351
In-Ho ChaeDepartment of Internal Medicine Seoul National University Bundang Hospital Seongnam South Korea.ORCID 0000-0003-1644-2105
Won-Yong ShinDepartment of Internal Medicine Soonchunhyang University Cheonan Hospital Cheonan South Korea.ORCID 0000-0002-1517-7189
Ju Hyeon OhDepartment of Cardiology, Samsung Changwon Hospital Sungkyunkwan University School of Medicine Changwon South Korea.
Yong Hoon KimDepartment of Internal Medicine Kangwon National University School of Medicine Chuncheon South Korea.ORCID 0000-0002-9669-3598
Tae-Ho ParkDepartment of Internal Medicine Dong-A University Hospital Busan South Korea.
Bum Soo KimDepartment of Internal Medicine, Kangbuk Samsung Hospital Sungkyunkwan University Seoul South Korea.
Jung-Kyu HanDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.ORCID 0000-0002-0016-0747
Eun-Seok ShinDepartment of Internal Medicine Ulsan University Hospital Ulsan South Korea.ORCID 0000-0002-9169-6968
Hyo-Soo KimDepartment of Internal Medicine, Cardiovascular Center Seoul National University Hospital Seoul South Korea.ORCID 0000-0003-0847-5329

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClopidogrel monotherapy improved clinical outcomes compared with aspirin monotherapy during a chronic maintenance period in patients who underwent coronary stenting in the HOST-EXAM (Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis-Extended Antiplatelet Monotherapy) trial. However, it is uncertain whether the beneficial effect of clopidogrel over aspirin is different according to the renal function. METHODS AND

resultsWe conducted a post hoc analysis of the HOST-EXAM trial. Chronic kidney disease (CKD) was defined as baseline estimated glomerular filtration rate <60 mL/min per 1.73 m

conclusionsDuring the chronic maintenance period after coronary stenting, the risk of thrombotic and bleeding events was significantly higher in patients with CKD compared with those without CKD. There was no statistical difference in the treatment effect of clopidogrel monotherapy in those with versus without CKD.

Indexed as

AspirinClopidogrelPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsRenal Insufficiency, ChronicAgedCoronary Artery DiseaseFemaleGlomerular Filtration RateHemorrhageHumansMaleMiddle AgedStentsTime FactorsTreatment OutcomeAspirinClopidogrelPlatelet Aggregation Inhibitorsaspirinchronic kidney diseaseclopidogrelpercutaneous coronary intervention

Identifiers

PMID39248265
PMCPMC11935617

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.