Evidence map›Paper›PMID 39248259›Full record

ArticleJournal of the American Heart Association2024

Pharmacist Use of a Population Management Dashboard for Safe Anticoagulant Prescribing: Evaluation of a Nationwide Implementation Effort.

Geoffrey D Barnes, Charity Chen, Rob Holleman, Joshua Errickson, F Jacob Seagull, Michael P Dorsch, Arthur L Allen, Patrick Spoutz, Jeremy B Sussman

Abstract readMulticenter Study
In one paragraph

Article in Journal of the American Heart Association, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Trial
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  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Geoffrey D BarnesFrankel Cardiovascular Center University of Michigan Ann Arbor MI.ORCID 0000-0002-6532-8440
Charity ChenCenter for Clinical Management Research Ann Arbor Veterans Affairs Ann Arbor MI.ORCID 0009-0006-4353-8785
Rob HollemanCenter for Clinical Management Research Ann Arbor Veterans Affairs Ann Arbor MI.
Joshua ErricksonCenter for Statistical Consultation and Research University of Michigan Ann Arbor MI.ORCID 0000-0002-4289-1417
F Jacob SeagullCenter for Bioethics and Social Science in Medicine University of Michigan Ann Arbor MI.ORCID 0000-0001-8075-1637
Michael P DorschFrankel Cardiovascular Center University of Michigan Ann Arbor MI.ORCID 0000-0003-2910-1879
Arthur L AllenVeterans Affairs Salt Lake City Health Care System Salt Lake City UT.ORCID 0000-0002-0508-1183
Patrick SpoutzPharmacy Benefits Management Veterans Integrates Service Network 20 Vancouver WA.ORCID 0000-0002-5617-1496
Jeremy B SussmanCenter for Clinical Management Research Ann Arbor Veterans Affairs Ann Arbor MI.ORCID 0000-0002-2158-3618

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDirect oral anticoagulants (DOACs) have complex dosing regimens and are often incorrectly prescribed. We evaluated a nationwide DOAC population management dashboard rollout whose purpose includes pharmacist review and correction of off-label dosing prescriptions. METHODS AND

resultsUsing data from Veterans Health Affairs, we identified all patients prescribed DOACs for atrial fibrillation or venous thromboembolism between August 2015 and December 2019. Sites were grouped on the basis of the timing of moderate-high usage of the DOAC population management tool dashboard. Effectiveness was defined as the monthly rate of off-label DOAC prescribing and the rate of clinical adverse events (bleeding, composite of stroke or venous thromboembolism). Implementation was evaluated as the percentage of off-label DOAC prescriptions changed within 7 days. Among the 128 652 patients receiving DOAC therapy at 123 centers, between 6.9% and 8.6% had off-label DOAC prescriptions. Adoption of the DOAC population management tool dashboard before July 2018 was associated with a decline in off-label dosing prescriptions (8.7%-7.6%). Only 1 group demonstrated a significant reduction in monthly rates of bleeding following implementation. All sites experienced a reduction in the composite of venous thromboembolism or stroke following dashboard adoption. There was no difference in the implementation outcome of DOAC prescription change within 7 days in any of the adoption groups.

conclusionsEarly adoption of the DOAC population management tool dashboard was associated with decreased rates of off-label DOAC dosing prescription and reduced bleeding. Following adoption of the DOAC population management tool dashboard, all sites experienced reductions in venous thromboembolism and stroke events.

Indexed as

Atrial FibrillationOff-Label UsePharmacistsVenous ThromboembolismAdministration, OralAgedAnticoagulantsDrug PrescriptionsFactor Xa InhibitorsFemaleHemorrhageHumansMalePractice Patterns, Physicians'StrokeUnited StatesAnticoagulantsFactor Xa Inhibitorsanticoagulationatrial fibrillationdrug use reviewpopulation health managementvenous thromboembolism

Identifiers

PMID39248259
PMCPMC11935639

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.