Evidence map›Paper›PMID 39248164›Full record

ArticleLiver international : official journal of the International Association for the Study of the Liver2024

The Freiburg Index of Post-TIPS Survival accurately predicts mortality in patients with acute decompensation of cirrhosis.

Eric Kalo, Lukas Sturm, Michael Schultheiss, Oliver Moore, Rajiv Kurup, Chiara Gahm, Scott Read, Marlene Reincke, Jan Patrick Huber, Lukas Müller and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Liver international : official journal of the International Association for the Study of the Liver, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Observational
  5. The Freiburg Index of Post-TIPS Survival accurately predicts mortality in patients with acute decompensation of cirrhosis.Liver international : official journal of the International Association for the Study of the Liver · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Eric KaloBlacktown Mount Druitt Clinical School and Research Centre, Western Sydney University, Blacktown, New South Wales, Australia.ORCID 0000-0002-6770-3857
Lukas SturmDepartment of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-3623-7857
Michael SchultheissDepartment of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0001-8000-1721
Oliver MooreBlacktown Hospital, Western Sydney Local Health District, Blacktown, New South Wales, Australia.
Rajiv KurupBlacktown Mount Druitt Clinical School and Research Centre, Western Sydney University, Blacktown, New South Wales, Australia.ORCID 0000-0001-8207-115X
Chiara GahmDepartment of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Scott ReadBlacktown Mount Druitt Clinical School and Research Centre, Western Sydney University, Blacktown, New South Wales, Australia.ORCID 0000-0001-6775-2061
Marlene ReinckeDepartment of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Jan Patrick HuberDepartment of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Lukas MüllerDepartment of Diagnostic and Interventional Radiology, Medical Center University of Mainz, Faculty of Medicine, University of Mainz, Mainz, Germany.
Roman KloecknerInstitute of Interventional Radiology, University Hospital Schleswig-Holstein, Lübeck, Germany.
Jacob GeorgeStorr Liver Unit, Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
Robert ThimmeDepartment of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Dominik BettingerDepartment of Medicine II, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-8782-8729
Golo AhlenstielBlacktown Mount Druitt Clinical School and Research Centre, Western Sydney University, Blacktown, New South Wales, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe recently developed Freiburg Index of Post-TIPS Survival (FIPS) allows improved risk classification of patients with decompensated cirrhosis allocated to transjugular intrahepatic portosystemic shunt (TIPS) implantation. This study investigated the prognostic value of the FIPS in patients hospitalized with acute decompensation of cirrhosis (AD), outside the setting of TIPS implantation.

methodsA total of 1133 patients with AD were included in a retrospective, multi-centre study. Ninety-day, 180-day and 1-year mortality were recorded and the FIPS' performance in predicting mortality at these time points was analysed using ROC analyses.

resultsNinety-day, 180-day and 1-year mortality were 17.7%, 24.4% and 30.8%. Uni- and multivariable Cox regression models showed that the FIPS independently predicted 1-year mortality in the study cohort (HR 1.806, 95% CI 1.632-1.998, p < .0001). In ROC analyses, the FIPS offered consistently high performance in the prediction of mortality within 1 year after AD (area under the receiver operator characteristic [AUROC]: 1-year mortality .712 [.679-.746], 180-day mortality .740 [.705-.775] and 90-day mortality .761 [.721-.801]). In fact, in the subgroup of patients presenting with variceal bleeding, the FIPS even showed significantly improved discriminatory performance in the prediction of long-term mortality (AUROC 1-year mortality: .782 [.724-.839]) in comparison with established prognostic scores, such as the CLIF-C AD score (.724 [.660-.788], p = .0071) or MELD 3.0 (.726 [.662-.790], p = .0042).

conclusionsThe FIPS accurately predicts mortality in patients with AD and seems to offer superior prognostication of long-term mortality in patients with variceal bleeding.

Indexed as

Liver CirrhosisPortasystemic Shunt, Transjugular IntrahepaticROC CurveAgedEsophageal and Gastric VaricesFemaleHumansMaleMiddle AgedMultivariate AnalysisPrognosisProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness Indexacute‐on‐chronic liver failuresurvivaltransjugular intrahepatic portosystemic shunt

Identifiers

PMID39248164
PMCPMC11586886

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.