ArticlePsychological bulletin
Psychological Stress During Childhood and Adolescence and Its Association With Inflammation Across the Lifespan: A Critical Review and Meta-Analysis.
Article in Psychological bulletin. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
68 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Parent-child separation and cardiometabolic outcomes and risk factors in adulthood: A systematic review.Psychoneuroendocrinology · 2023Pooled it
- Which outcome variables are associated with psychological inflexibility/flexibility for chronic pain patients? A three level meta-analysis.Frontiers in psychology · 2022Pooled it
- Associations of childhood maltreatment types and timing with oxidative stress in formerly out-of-home placed young adults.European journal of psychotraumatology · 2026Article
- Proteomic insights into childhood adversity: Exploring biological mechanisms and cognitive outcomes in the CARDIA study.Brain, behavior, & immunity - health · 2026Article
- A Hypothesis Linking Early-Life Adversity to Altered Synaptic Connectivity Through Disrupted Gut Microbiome-Microglia Communication.Nutrients · 2026Review
- Serum TLR4, NF-κB, and NLRP3 Levels in Children with Attention-Deficit/Hyperactivity Disorder: A Case-Control Study.Children (Basel, Switzerland) · 2026Article
- Impact of Chronic Stress and Trauma on Asthma Pathophysiology and Outcomes.Current allergy and asthma reports · 2026Review
- Examination of poverty trajectories and brain volume as predictors of adolescent depression.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2026Article
- Joint Effects of Adverse Childhood Experiences and Genetic Burden of Depression on Multiple Depressive Symptoms.Stress and health : journal of the International Society for the Investigation of Stress · 2026Article
- Inflammation, fronto-amygdala connectivity, and negative affective reactivity to daily stress in adolescents.Brain, behavior, & immunity - health · 2026Article
- Lifetime adversity exposure, mood symptoms, and immune mitochondrial bioenergetics.medRxiv : the preprint server for health sciences · 2026Article
- Dynamic Associations Between Negative Affect, Rumination, and Nonsuicidal Self-Injury in Daily Life: An Ecological Momentary Assessment Study of Adolescent Psychiatric Outpatients.Research on child and adolescent psychopathology · 2026Article
- State educational contexts in childhood and systemic inflammation in later life: Evidence from the health and retirement study.Brain, behavior, & immunity - health · 2026Article
- Dietary Inflammatory Index and Depressive Symptoms in Chinese University Students Leveraging an Intelligent Ordering System: 3-Year Longitudinal Prospective Cohort Study.Journal of medical Internet research · 2026Article
- Age-dependent associations of psychological and family factors on systemic inflammation in childhood acute lymphoblastic leukemia survivors.Journal of cancer survivorship : research and practice · 2026Article
- Adolescent residential mobility, local nasal inflammation, and adult susceptibility to the common cold.Brain, behavior, & immunity - health · 2026Article
- Temporomandibular disorders prevalence and associated factors among adolescents in Al-Ahsa, Saudi Arabia: a school-based cross-sectional study.BMC oral health · 2026Article
- Longitudinal trajectories of perceived stress during college transition: the protective roles of psychological resilience and social support.BMC psychology · 2026Article
- Psychobiological mechanisms underlying the association between early life stress and depression in adolescence.Molecular psychiatry · 2026Review
- Impact of Social Vulnerability and Allostatic Load on Postoperative Outcomes.Annals of surgical oncology · 2026Article
8 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Psychological stress during childhood and adolescence increases risk of health problems across the lifecourse, and inflammation is implicated as an underlying mechanism. To evaluate the viability of this hypothesis, we used meta-analysis to quantify the association between childhood/adolescent stress and inflammation over the lifecourse. Furthermore, we addressed three unresolved conceptual questions: (a) Does the strength of this association change over the lifecourse? (b) Are different types of childhood/adolescent stressors differentially associated with inflammation? (c) And which components of the inflammatory response are involved? A systematic search identified 187 articles reporting 922 associations. Meta-analyses were conducted using a three-level multilevel approach and controlled for study quality, conversion confidence, and whether effect sizes were unadjusted or adjusted (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.