Evidence map›Paper›PMID 39247814›Full record

ArticleInternational journal of biological sciences2024

Enhancing mitophagy by ligustilide through BNIP3-LC3 interaction attenuates oxidative stress-induced neuronal apoptosis in spinal cord injury.

Hui Yao, Chaoyang Cai, Weijun Huang, Caizhen Zhong, Tianlun Zhao, Jiawei Di, Juliang Tang, Depeng Wu, Mao Pang, Lei He and 2 more

Abstract read
In one paragraph

Article in International journal of biological sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  5. Pharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hui YaoDepartment of Orthopaedics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Chaoyang CaiDepartment of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Weijun HuangDepartment of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Caizhen ZhongDepartment of Gastroenterology and Rheumatology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Tianlun ZhaoDepartment of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Jiawei DiDepartment of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Juliang TangDepartment of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Depeng WuDepartment of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Mao PangDepartment of Orthopaedics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Lei HeDepartment of Orthopaedics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Limin RongDepartment of Orthopaedics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.
Bin LiuDepartment of Orthopaedics, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mitophagy selectively eliminates damaged or dysfunctional mitochondria, playing a crucial role in maintaining mitochondrial quality control. However, it remains unclear whether mitophagy can be fully activated and how it evolves after SCI. Our RNA-seq analysis of animal samples from sham and 1, 3, 5, and 7 days post-SCI indicated that mitophagy was indeed inhibited during the acute and subacute early stages.

Indexed as

4-ButyrolactoneApoptosisMembrane ProteinsMitophagyNeuronsOxidative StressRats, Sprague-DawleySpinal Cord InjuriesAnimalsMaleMicrotubule-Associated ProteinsMitochondriaMitochondrial ProteinsRatsReactive Oxygen Species4-ButyrolactoneAnxa3 protein, ratBNIP3 protein, ratligustilideMembrane ProteinsMicrotubule-Associated ProteinsMitochondrial ProteinsReactive Oxygen Speciesligustilidemitochondrial autophagyneuronal apoptosisnon-ubiquitination processROSspinal cord injury

Identifiers

PMID39247814
PMCPMC11379069

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.