Evidence map›Paper›PMID 39247794›Full record

Trial reportDrug design, development and therapy2024

Efficacy and Safety of General Anesthesia Induction with Ciprofol in Hip Fracture Surgery of Elderly Patients: A Randomized Controlled Trial.

Yan-Fei Lu, Ji-Min Wu, Hai-Yan Lan, Qiao-Min Xu, Shu-Qi Shi, Gong-Chen Duan

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug design, development and therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 4 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yan-Fei Lu *Center for Rehabilitation Medicine, Department of Anesthesiology, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, People's Republic of China.
Ji-Min Wu *Department of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, People's Republic of China.
Hai-Yan LanDepartment of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, People's Republic of China.
Qiao-Min XuDepartment of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, People's Republic of China.ORCID 0009-0000-7716-6488
Shu-Qi ShiDepartment of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, People's Republic of China.
Gong-Chen DuanDepartment of Anesthesiology, Lishui People's Hospital, Wenzhou Medical University Lishui Hospital, Lishui, People's Republic of China.ORCID 0000-0001-6680-3031

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ciprofol is a new intravenous sedative / anesthetic drug. In recent years, many clinical studies have also confirmed the sedative effect of ciprofol. However, more clinical research is still needed on its clinical application characteristics in special populations. Objective: The aim of this study was to compare the clinical effects of ciprofol and propofol in general anesthesia induction of elderly patients. Methods: 60 elderly (aged ≥ 75 years) patients underwent hip fracture surgery were randomly into two groups of a 1:1 ratio. Group C (ciprofol group): 0.3mg/kg ciprofol was infused. Group P (propofol group): 1.5mg/kg propofol was infused. The observation period was from the infusion of test drug to 5 min after endotracheal intubation. The primary outcomes included the incidence of severe hypotension and hypotension during the observation period. The secondary outcomes were as follows: the success rate of general anesthesia induction, the number of additional sedation, the time of loss of consciousness (LOC), Δ MAP, Δ HR, adverse events and the frequency of vasoactive drugs used. Results: Finally, 60 subjects completed the study. Compared with Group P, the incidence of severe hypotension in Group C was lower (26.7% vs 53.3%, Conclusion: Ciprofol showed similar efficacy to propofol when used for general anesthesia induction in elderly patients underwent hip fracture surgery and could maintain more stable blood pressure.

Indexed as

Anesthesia, GeneralHip FracturesPropofolAgedAged, 80 and overAnesthetics, IntravenousFemaleHumansMaleAnesthetics, IntravenousPropofolCiprofolelderlygeneral anesthesiaHip fracture surgeryhypotension

Identifiers

PMID39247794
PMCPMC11380857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.