ArticleFrontiers in microbiology2024
Causal effects of gut microbiota on risk of overactive bladder symptoms: a two-sample Mendelian randomization study.
Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- URICA Study: Diagnosis and Management of Recurrent Acute Bacterial Cystitis in Women With Urinary Behavioral Therapy.Infectious diseases and therapy · 2026Article
- Association between early age at menarche and overactive bladder risk in women: insights from NHANES and Mendelian randomization analysis.Translational andrology and urology · 2025Article
- Association between exposure to blood heavy metal mixtures and overactive bladder risk among U.S. adults: a cross-sectional study.Frontiers in public health · 2025Article
- Recurrent urinary tract infections and psychological burden: mechanisms and integrative perspectives.Frontiers in medicine · 2025Review
- Associations of overactive bladder (OAB) with suicidal ideation incidence and all-cause mortality among the U.S. population.BMC psychiatry · 2024Article
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Authors and funding
6 authors.
Funding
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Abstract
Background: Clinical observations indicate a correlation between the gut microbiota and overactive bladder (OAB) symptoms. Nevertheless, the causal relationship and mechanisms between gut microbiota and OAB symptoms remain elusive. Methods: Two-sample Mendelian randomization (MR) analyses were performed to assess the association between gut microbiota and OAB symptoms, including urinary incontinence (UI). Data were obtained from the MiBioGen International Consortium genome-wide association studies (GWAS) dataset and the IEU GWAS database. The inverse variance weighted method was used as the primary approach in the MR analysis, with the weighted median, MR-Egger, and weighted mode methods as supplementary approaches. Sensitivity analyses were employed to assess potential violations of the MR assumptions. Results: Our analysis identified seven gut bacterial taxa with a causal relationship to OAB and nine gut bacterial taxa associated with UI. Genera Conclusion: This study revealed a causal relationship between gut microbiota and OAB symptoms, providing new insights and a theoretical foundation to identify biomarkers and therapeutic targets for patients with OAB symptoms.
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