ArticleFrontiers in medicine2024
The association between the aggregate index of systemic inflammation and risk of rheumatoid arthritis: retrospective analysis of NHANES 1999-2018.
Article in Frontiers in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Pericoronary adipose tissue as a biomarker of coronary atherosclerosis and cardiovascular risk in rheumatoid arthritis.Rheumatology (Oxford, England) · 2026Observational
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- The Nonlinear Relationship Between the Aggregate Index of Systemic Inflammation and Serum Neurofilament Light Chain Levels in U.S. Adults: A Cross-Sectional Study.Mediators of inflammation · 2026Article
- Machine learning based on systemic inflammation response index and risk of cardiovascular disease in gout: a retrospective study and clinical validation.Clinical rheumatology · 2026Article
- Inflammation Beyond the Prostate: The Role of Systemic Inflammatory Disorders in Prostate Carcinogenesis.Cureus · 2025Review
- Association of the aggregate index of systemic inflammation in cancer survivors with all-cause, cardiovascular, and cancer-related mortality.Translational cancer research · 2025Article
- Evaluation of Systemic Inflammatory Indices of Earthquake Victims After the 6 February Kahramanmaraş Earthquake.Thoracic research and practice · 2025Article
- Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients.Scientific reports · 2025Article
- Association between rheumatoid arthritis and kidney stones: A cross-sectional study of NHANES 2007-2020.Arthritis research & therapy · 2025Article
- Obesity indicators mediate the association between the aggregate index of systemic inflammation (AISI) and type 2 diabetes mellitus (T2DM).Lipids in health and disease · 2025Article
- Aggregate index of systemic inflammation as a novel prognostic biomarker in Chinese patients with acute decompensated heart failure: a population-based real-world study.Frontiers in endocrinology · 2025Article
- Machine learning based association between inflammation indicators (NLR, PLR, NPAR, SII, SIRI, and AISI) and all-cause mortality in arthritis patients with hypertension: NHANES 1999-2018.Frontiers in public health · 2025Article
- Association of aggregate index of systemic inflammation with increased all-cause and cardiovascular mortality in female cancer patients.Frontiers in oncology · 2025Article
- Association between the aggregate index of systemic inflammation and CKD: evidence from NHANES 1999-2018.Frontiers in medicine · 2025Article
- Inflammation Promotes Insulin Resistance: Analysis Based on Inflammation Indices Obtained from the Complete Blood Count.Journal of inflammation research · 2025Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: The investigation purpose was to examine the correlation between the aggregate index of systemic inflammation (AISI) and rheumatoid arthritis (RA) by utilizing the NHANES database from the years 1999 to 2018. Methods: The NHANES database was utilized to extract data spanning from 1999 to 2018. AISI, comprising neutrophils (NEU), monocytes (MONO), platelets (PLT), and lymphocytes (LYM), was computed based on counts. The identification of RA patients was accomplished through questionnaire data. To investigate the connection between AISI and RA, a weighted multivariate regression and subgroup analysis were conducted. In addition, restricted cubic splines (RCS) were employed for examining non-linear associations. Results: The study encompassed a total of 41,986 patients, among whom 2,642 (6.29%) were diagnosed with RA. Upon controlling for all covariates, the outcomes of the multivariate logistic regression assay demonstrated a statistically significant association between higher Ln(AISI) levels and elevated odds of RA (odds ratio [OR]: 1.097; 95% confidence interval [CI]: 1.096-1.099, Conclusion: Overall, a positive association has been observed between AISI and RA. This study highlights the potential of AISI as an innovative, vital, and appropriate inflammatory biomarker for predicting the risk of developing rheumatoid arthritis in older individuals residing in the United States.
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