Evidence map›Paper›PMID 39247613›Full record

ArticleCurrent opinion in behavioral sciences2024

Shifting attention to orient or avoid: a unifying account of the tail of the striatum and its dopaminergic inputs.

Isobel Green, Ryunosuke Amo, Mitsuko Watabe-Uchida

Abstract read
In one paragraph

Article in Current opinion in behavioral sciences, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Article
  3. Anabolic androgenic steroids induce distinct monoaminergic and lipidomic alterations in the male rat brain.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Striatal Gradient in Value-Decay Explains Regional Differences in Dopamine Patterns and Reinforcement Learning Computations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  13. Unraveling Pallido-Retrorubral Circuits Linking the Basal Ganglia to Limbic Areas.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  14. Review
  15. Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Isobel GreenDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Ryunosuke AmoDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Mitsuko Watabe-UchidaDepartment of Molecular and Cellular Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
Molecular Codes for the Establishment of Functionally Segregated Dopaminergic CircuitsR01MH125162 · NIMH · BOSTON CHILDREN'S HOSPITAL · PI UMEMORI, HISASHI, WATABE-UCHIDA, MITSUKO · 2021 to 2025
$4.1M
Basal ganglia circuit mechanisms for threat copingR01MH133950 · NIMH · HARVARD UNIVERSITY · PI UCHIDA, NAOSHIGE, WATABE-UCHIDA, MITSUKO · 2023 to 2025
$2.0M
Investigating the impact of chronic stress on distinct axes of dopamine signalingF30MH132298 · NIMH · HARVARD MEDICAL SCHOOL · PI GREEN, ISOBEL WOUK · 2023 to 2025
$146k
NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIMH NIH HHS F30 MH132298NIMH NIH HHS R01 MH125162NIMH NIH HHS R01 MH133950
6 · The paper itself

Abstract

The tail of the striatum (TS) is increasingly recognized as a unique subdivision of the striatum, characterized by its dense sensory inputs and projections received from a distinct group of dopamine neurons. Separate lines of research have characterized the functional role of TS, and TS-projecting dopamine neurons, in three realms: saccadic eye movement towards valuable visual stimuli; tone-guided choice between two options; and defensive responses to threatening stimuli. We propose a framework for reconciling these diverse roles as varied implementations of a conserved response to salient stimuli, with dopamine in TS providing a teaching signal to promote quick attentional shifts that facilitate stimulus-driven orientation and/or avoidance.

Identifiers

PMID39247613
PMCPMC11376218

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.