Evidence map›Paper›PMID 39247561›Full record

ArticleClinical case reports2024

Individualized tacrolimus therapy: Insights from CYP3A5 polymorphisms and intestinal metabolism.

Mizuki Mishima, Tomohisa Yabe, Takaya Kondo, Keiji Fujimoto, Ryoji Takata, Hitoshi Yokoyama, Yo Niida, Tatsuro Tanaka, Katsuhito Miyazawa, Kengo Furuichi

Abstract readCase Reports
In one paragraph

Article in Clinical case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mizuki MishimaDepartment of Nephrology Kanazawa Medical University Kahoku Japan.ORCID https://orcid.org/0009-0007-0072-2870
Tomohisa YabeDepartment of Nephrology Kanazawa Medical University Kahoku Japan.
Takaya KondoDepartment of Nephrology Kanazawa Medical University Kahoku Japan.
Keiji FujimotoDepartment of Nephrology Kanazawa Medical University Kahoku Japan.
Ryoji TakataDepartment of Pharmacy Kanazawa Medical University Hospital Kahoku Japan.
Hitoshi YokoyamaDepartment of Nephrology Kanazawa Medical University Kahoku Japan.
Yo NiidaDivision of Genomic Medicine, Department of Advanced Medicine, Medical Research Institute Kanazawa Medical University Kahoku Japan.
Tatsuro TanakaDepartment of Urology Kanazawa Medical University Kahoku Japan.
Katsuhito MiyazawaDepartment of Urology Kanazawa Medical University Kahoku Japan.
Kengo FuruichiDepartment of Nephrology Kanazawa Medical University Kahoku Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CYP3A4 and CYP3A5 are the most abundant and important enzymes of the CYP3A subfamily, distributed in the liver, intestinal mucosa and kidney, and involved in tacrolimus metabolism. Here, we report a case of tacrolimus dosage refractoriness due to a genetic polymorphism of

Indexed as

CYP3A5intestinal absorptionkidney transplantationtacrolimustherapeutic drug monitoring

Identifiers

PMID39247561
PMCPMC11377175

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.