Evidence map›Paper›PMID 39247254›Full record

ArticleJournal of polymer science (2020)2024

Biodegradable Zwitterionic Polymers as PEG Alternatives for Drug Delivery.

Ziwen Zhang, Haotian Sun, Justin Giannino, Yun Wu, Chong Cheng

Abstract read
In one paragraph

Article in Journal of polymer science (2020), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. Review
  3. Tissue-specific gene delivery approaches.Bioengineering & translational medicine · 2026
    Review
  4. Article
  5. Review
  6. Review
  7. Environmental and Ecological Monitoring with Biodegradable Technologies.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  8. Polymeric Nanocarriers with pH-Dependent Release for Tumor-Specific Delivery.Recent advances in drug delivery and formulation · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ziwen ZhangDepartment of Chemical and Biological Engineering, University at Buffalo, the State University of New York, Buffalo, NY 14260.
Haotian SunDepartment of Chemical and Biological Engineering, University at Buffalo, the State University of New York, Buffalo, NY 14260.
Justin GianninoDepartment of Biomedical Engineering, University at Buffalo, the State University of New York, Buffalo, NY 14260.
Yun WuDepartment of Biomedical Engineering, University at Buffalo, the State University of New York, Buffalo, NY 14260.
Chong ChengDepartment of Chemical and Biological Engineering, University at Buffalo, the State University of New York, Buffalo, NY 14260.

Funding

Multifunctional Biodegradable Zwitterionic Polymer-Drug Conjugates for Multidrug Co-DeliveryR01EB034306 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI Chong Cheng · 2023 to 2026
$2.4M
Zwitterionic Dendrimer-modified PEG for Protein ConjugationR21EB032240 · NIBIB · STATE UNIVERSITY OF NEW YORK AT BUFFALO · PI CHENG, CHONG, WU, YUN · 2021 to 2022
$434k
NIBIB NIH HHS R01 EB034306NIBIB NIH HHS R21 EB032240
6 · The paper itself

Abstract

Poly(ethylene glycol) (PEG) is a highly biocompatible and water-soluble polymer that is widely utilized for biomedical applications. Unfortunately, the immunogenicity and antigenicity of PEG severely restrict the biomedical efficacy of pegylated therapeutics. As emerging PEG alternatives, biodegradable zwitterionic polymers (ZPs) have attracted significant interest in recent years. Biodegradable ZPs generally are not only water-soluble and immunologically inert, but also possess a range of favorable biomedically relevant properties, without causing long-term side effects for

Indexed as

biodegradable polymerdrug deliveryPEG alternativeprotein deliveryzwitterionic polymer

Identifiers

PMID39247254
PMCPMC11376432

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.