Evidence map›Paper›PMID 39247144›Full record

ArticleNature. Mental health2024

No Replication of Alzheimer's Disease Genetics as a Moderator of Combat Exposure's Association with PTSD risk in 138,592 Combat Veterans.

Erika J Wolf, Mark W Miller, Rui Zhang, Richard Sherva, Kelly M Harrington, Jennifer R Fonda, Nikolaos P Daskalakis, J Michael Gaziano, Mark W Logue

Abstract read
In one paragraph

Article in Nature. Mental health, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erika J WolfNational Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, 02130, USA.
Mark W MillerNational Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, 02130, USA.
Rui ZhangNational Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, 02130, USA.
Richard ShervaBoston University Chobanian & Avedisian School of Medicine, Biomedical Genetics, Boston, MA, 02118, USA.
Kelly M HarringtonBoston University Chobanian & Avedisian School of Medicine, Department of Psychiatry, Boston, MA, 02118, USA.
Jennifer R FondaBoston University Chobanian & Avedisian School of Medicine, Department of Psychiatry, Boston, MA, 02118, USA.
Nikolaos P DaskalakisHarvard Medical School, Department of Psychiatry, Boston, MA, 02215, USA.
J Michael GazianoMassachusetts Veterans Epidemiology Research and Information Center (MAVERIC), VA Boston Healthcare System, Boston, MA, 02130, USA.
Mark W LogueNational Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, 02130, USA.

Funding

Early Cognitive Impairment as a Function of Alzheimer’s Disease Genes and TraumaI01BX004192 · VA · VA BOSTON HEALTH CARE SYSTEM · PI LOGUE, MARK W · 2019 to 2024
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Early Cognitive Impairment as a function of Alzheimer's Disease and TraumaI01BX005749 · VA · VA BOSTON HEALTH CARE SYSTEM · PI MARK W LOGUE · 2023 to 2026
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Predictor Profiles of Opioid Use Disorders and Overdose Among Post-9/11 VeteransIK2CX002192 · VA · VA BOSTON HEALTH CARE SYSTEM · PI Jennifer R Fonda · 2022 to 2026
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BLRD VA I01 BX004192BLRD VA I01 BX005749CSRD VA IK2 CX002192
6 · The paper itself

Abstract

Large-scale cohort and epidemiological studies suggest that posttraumatic stress disorder (PTSD) confers risk for late-onset Alzheimer's disease (AD) and related dementias (ADRD); however, the basis for this association remains unclear. Several prior studies of military Veterans have reported that carriers of the apolipoprotein E (

Indexed as

Alzheimer’s diseaseAPOEcombat exposureG X EPTSDtraumatic brain injury

Identifiers

PMID39247144
PMCPMC11378975

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.