Evidence map›Paper›PMID 39247062›Full record

ArticleJournal of hematology2024

Optic Disc Infiltration as a Sign of Multiple Myeloma Recurrence.

Maria Pantelidou, Eleni Dimitriou, Konstantinos Gkontopoulos, Thomas Thomopoulos, Vasiliki Pappa, Sotirios G Papageorgiou, Panagiotis Theodossiadis, Irini Chatziralli

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In one paragraph

Article in Journal of hematology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Pantelidou2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Eleni Dimitriou2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Konstantinos Gkontopoulos2nd Department of Propaedeutic Internal Medicine, Hematology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Thomas Thomopoulos2nd Department of Propaedeutic Internal Medicine, Hematology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Vasiliki Pappa2nd Department of Propaedeutic Internal Medicine, Hematology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Sotirios G Papageorgiou2nd Department of Propaedeutic Internal Medicine, Hematology Unit, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Panagiotis Theodossiadis2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Irini Chatziralli2nd Department of Ophthalmology, Attikon University Hospital, National and Kapodistrian University of Athens, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multiple myeloma is a plasma cell dyscrasia with an age-standardized incidence of 3 - 4 per 100,000 in the Caucasian population. It is the second most common hematological malignancy after non-Hodgkin lymphoma, representing 1% of all cancers. Herein, we present a case report of multiple myeloma with ocular involvement as a sign of recurrence. A 62-year-old woman, with a known history of lambda light chain multiple myeloma, presented with reduced visual acuity in both eyes while on maintenance chemotherapy. The patient also had mild unsteadiness and fatigue. Fundus examination revealed bilateral optic disc swelling and hemorrhages of the posterior pole. Magnetic resonance imaging disclosed no abnormalities. Although no biopsy of the optic nerve was possible, intracranial pressure was elevated and cerebrospinal fluid was riddled with neoplastic cells, affirming the diagnosis. After 2 months of chemotherapy, visual function and the appearance of the posterior pole returned to normal. In cases of multiple myeloma, mechanisms, such as hyperviscosity syndrome, microvascular impairment and optic nerve and meningeal infiltration on a cellular level may have played a pivotal role in the ocular involvement, which can be the first sign of recurrence.

Indexed as

Multiple myelomaOcular involvementOptic disc infiltrationRecurrence

Identifiers

PMID39247062
PMCPMC11379052

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