Evidence map›Paper›PMID 39246838›Full record

ArticleBioactive materials2024

A biodegradable microgrooved and tissue mechanocompatible citrate-based scaffold improves bladder tissue regeneration.

Madeleine Goedegebuure, Matthew I Bury, Xinlong Wang, Pasquale Sanfelice, Federico Cammarata, Larry Wang, Tiffany T Sharma, Nachiket Rajinikanth, Vikram Karra, Vidhika Siddha and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioactive materials, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Madeleine GoedegebuureDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Matthew I BuryDepartment of Surgery, Division of Urology, Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Xinlong WangDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Pasquale SanfeliceDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Federico CammarataDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Larry WangDepartment of Urology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
Tiffany T SharmaDepartment of Surgery, Division of Urology, Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Nachiket RajinikanthDepartment of Surgery, Division of Urology, Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Vikram KarraDepartment of Surgery, Division of Urology, Lurie Children's Hospital of Chicago, Chicago, IL, USA.
Vidhika SiddhaDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Arun K SharmaDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.
Guillermo A AmeerDepartment of Biomedical Engineering, Northwestern University, Evanston, IL, USA.

Funding

Developing a SMART scaffold for bladder augmentationR01EB026572 · NIBIB · NORTHWESTERN UNIVERSITY · PI Guillermo Antonio Ameer, John Rogers · 2019 to 2026
$4.0M
Nonhuman Primate Model of Bladder Regeneration Using Autologous Bone Marrow CellsR01DK109539 · NIDDK · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SHARMA, ARUN · 2017 to 2021
$3.4M
Regenerative Engineering Training Program (RE-Training)T32EB031527 · NIBIB · NORTHWESTERN UNIVERSITY · PI Guillermo Antonio Ameer · 2021 to 2026
$1.3M
NIBIB NIH HHS R01 EB026572NIBIB NIH HHS T32 EB031527NIDDK NIH HHS R01 DK109539
6 · The paper itself

Abstract

Chronic bladder dysfunction due to bladder disease or trauma is detrimental to affected patients as it can lead to increased risk of upper urinary tract dysfunction. Current treatment options include surgical interventions that enlarge the bladder with autologous bowel tissue to alleviate pressure on the upper urinary tract. This highly invasive procedure, termed bladder augmentation enterocystoplasty (BAE), significantly increases the risk of patient morbidity and mortality due to the incompatibility between bowel and bladder tissue. Therefore, patients would significantly benefit from an alternative treatment strategy that can regenerate healthy tissue and restore overall bladder function. Previous research has demonstrated the potential of citrate-based scaffolds co-seeded with bone marrow-derived stem/progenitor cells as an alternative graft for bladder augmentation. Recognizing that contact guidance can potentially influence tissue regeneration, we hypothesized that microtopographically patterned scaffolds would modulate cell responses and improve overall quality of the regenerated bladder tissue. We fabricated microgrooved (MG) scaffolds using the citrate-based biomaterial poly (1,8-octamethylene-citrate-

Indexed as

Guided bladder tissue regenerationHematopoietic stem cellMesenchymal stem cellMicrotopographyNeovascularization

Identifiers

PMID39246838
PMCPMC11380464

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.