Evidence map›Paper›PMID 39246769›Full record

ArticleSurgical neurology international2024

Clinico-radio-pathological predictors of outcomes in patients with acromegaly undergoing endoscopic transsphenoidal surgery.

Sanish Ancil, Kirti Gupta, Subin S, Liza Das, Chirag Kamal Ahuja, Rajesh Chhabra, Sivashanmugam Dhandapani, Pinaki Dutta

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical neurology international, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sanish AncilDepartment of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Kirti GuptaDepartment of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Subin SDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Liza DasDepartment of Endocrinology and Telemedicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Chirag Kamal AhujaDepartment of Radiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Rajesh ChhabraDepartment of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Sivashanmugam DhandapaniDepartment of Neurosurgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Pinaki DuttaDepartment of Endocrinology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acromegaly is a rare chronic endocrine disorder with variable biochemical remission rates from 40% to 85%. Hence, understanding the factors predicting biochemical cures helps in planning targeted and personalized treatment. We aimed to study the various clinico-radio-pathological predictors of outcomes in patients with pituitary neuroendocrine tumor (PitNET) who underwent transsphenoidal surgery (TSS) at 3 months follow-up. Methods: Our cohort included 61 consecutive patients with acromegaly treated at an institute in northwest India between January 2019 and June 2021. The outcomes of TSS were assessed at the end of 3 months postoperatively as defined by Endocrine Society Guidelines 2014. Results: The mean age at diagnosis was 38 ± 12 years, with the majority being females (67.2%). The median tumor volume was 2376 mm Conclusion: Overall, bulky tumors, higher hormone burden, and advanced Knosp grades translated to lower rates of biochemical remission in the present study cohort. Contrary to earlier studies, conventional IHC markers such as Ki-67, SSTR2/5, and CAM5.2 were not useful for predicting biochemical remission at 3 months.

Indexed as

AcromegalyHistopathologyPituitary neuroendocrine tumor (PitNET)RadiologyRemissionTranssphenoidal surgery

Identifiers

PMID39246769
PMCPMC11380812

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.