Evidence map›Paper›PMID 39246739›Full record

ArticleNeurology. Genetics2024

Genome-Wide and Transcriptome-Wide Association Studies on Northern New England and Ohio Amyotrophic Lateral Sclerosis Cohorts.

Siting Li, Jiang Gui, Michael N Passarelli, Angeline S Andrew, Kathleen M Sullivan, Kevin A Cornell, Bryan J Traynor, Ali Stark, Ruth Chia, Rebecca M Kuenzler and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology. Genetics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Siting LiFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.ORCID https://orcid.org/0000-0003-2523-4201
Jiang GuiFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.ORCID https://orcid.org/0000-0001-5377-8914
Michael N PassarelliFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.
Angeline S AndrewFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.
Kathleen M SullivanFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.
Kevin A CornellFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.ORCID https://orcid.org/0000-0002-2634-9759
Bryan J TraynorFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.
Ali StarkFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.
Ruth ChiaFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.ORCID https://orcid.org/0000-0002-4709-7423
Rebecca M KuenzlerFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.
Erik P PioroFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.
Walter G BradleyFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.
Elijah W StommelFrom the Departments of Biomedical Data Science (S.L., J.G.), Epidemiology (S.L., M.N.P.), and Neurology, Geisel School of Medicine at Dartmouth (E.W.S.), Dartmouth College, Hanover; Dartmouth Health (A.S.A., K.M.S., K.A.C., E.W.S.), Lebanon, NH; Neuromuscular Diseases Research Section (B.J.T., A.S., R.C.), National Institute on Aging; National Institute of Neurological Disorders and Stroke (B.J.T.), National Institutes of Health, Bethesda; RNA Therapeutics Laboratory (B.J.T.), National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD; Cleveland Clinic (R.M.K.), OH; Department of Medicine (E.P.P.), University of British Columbia, Vancouver, BC, Canada; and University of Miami Miller School of Medicine (W.G.B.), FL.ORCID https://orcid.org/0000-0002-3079-3123

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and Objectives: Amyotrophic lateral sclerosis (ALS) is an age-associated, fatal neurodegenerative disorder causing progressive paralysis and respiratory failure. The genetic architecture of ALS is still largely unknown. Methods: We performed a genome-wide association study (GWAS) and transcriptome-wide association study (TWAS) to understand genetic risk factors for ALS using a population-based case-control study of 435 ALS cases and 279 controls from Northern New England and Ohio. Single nucleotide polymorphism (SNP) genotyping was conducted using the Illumina NeuroChip array. Odds ratios were estimated using covariate-adjusted logistic regression. We also performed a genome-wide SNP-smoking interaction screening. TWAS analyses used PrediXcan to estimate associations between predicted gene expression levels across 15 tissues (13 brain tissues, skeletal muscle, and whole blood) and ALS risk. Results: GWAS analyses identified the p.A382T missense variant (rs367543041, Discussion: Our results support the need for future evaluation to clarify the role of these potential genetic risk factors for ALS and to understand genetic susceptibility to environmental risk factors.

Identifiers

PMID39246739
PMCPMC11380502

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