Evidence map›Paper›PMID 39246659›Full record

ArticleFrontiers in pharmacology2024

Design and evaluation of magnetic-targeted bilosomal gel for rheumatoid arthritis: flurbiprofen delivery using superparamagnetic iron oxide nanoparticles.

Rayan Y Mushtaq, Nimbagal Raghavendra Naveen, Krishna Jayanth Rolla, Humood Al Shmrany, Sameer Alshehri, Ahmad Salawi, Mallesh Kurakula, Majed A Alghamdi, Waleed Y Rizg, Rana B Bakhaidar and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rayan Y MushtaqDepartment of Pharmaceutics, College of Clinical Pharmacy, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia.
Nimbagal Raghavendra NaveenDepartment of Pharmaceutics, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, Mandya, Karnataka, India.
Krishna Jayanth RollaDepartment of Data Analytics, Global Technical Software Service, Inc. (GTSS), Hamilton, NJ, United States.
Humood Al ShmranyDepartment of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Alkharj, Saudi Arabia.
Sameer AlshehriDepartment of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, Taif, Saudi Arabia.
Ahmad SalawiDepartment of Pharmaceutics, College of Pharmacy, Jazan University, Jazan, Saudi Arabia.
Mallesh KurakulaThermo Fisher Scientific, Bend, OR, United States.
Majed A AlghamdiDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdualziz University, Jeddah, Saudi Arabia.
Waleed Y RizgDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdualziz University, Jeddah, Saudi Arabia.
Rana B BakhaidarDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdualziz University, Jeddah, Saudi Arabia.
Walaa A AbualsununDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdualziz University, Jeddah, Saudi Arabia.
Khaled M HosnyDepartment of Pharmaceutics, Faculty of Pharmacy, King Abdualziz University, Jeddah, Saudi Arabia.
Abdulmohsin J AlamoudiDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah, Saudi Arabia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The study aimed to systematically enhance the fabrication process of flurbiprofen-loaded bilosomes (FSB) using Quality by Design (QbD) principles and Design of Experiments (DOE). The objective was to develop an optimized formulation with improved entrapment efficiency and targeted drug delivery capabilities. Methods: The optimization process involved applying QbD principles and DOE to achieve the desired formulation characteristics. Superparamagnetic iron oxide nanoparticles (SPIONs) were incorporated to impart magnetic responsiveness. The size, entrapment efficiency, morphology, and Results: The optimized FSB formulation yielded particles with a size of 453.60 nm and an entrapment efficiency of 91.57%. The incorporation of SPIONs enhanced magnetic responsiveness. Morphological evaluations and Discussion: This comprehensive investigation highlights the potential of FSB as a promising targeted drug delivery system for the effective management of osteoarthritis. The use of QbD and DOE in the formulation process, along with the integration of SPIONs, resulted in an optimized FSB formulation with enhanced entrapment efficiency and targeted delivery capabilities. The

Indexed as

design of experimentsflubiprofen-loaded bilosomesosteoarthritis managementquality by designsuperparamagnetic iron oxide nanoparticlestargeted drug delivery

Identifiers

PMID39246659
PMCPMC11377347

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.