Evidence map›Paper›PMID 39246594›Full record

ArticleFrontiers in aging neuroscience2024

Exercise and brain health in patients with coronary artery disease: study protocol for the HEART-BRAIN randomized controlled trial.

Angel Toval, Patricio Solis-Urra, Esmée A Bakker, Lucía Sánchez-Aranda, Javier Fernández-Ortega, Carlos Prieto, Rosa María Alonso-Cuenca, Alberto González-García, Isabel Martín-Fuentes, Beatriz Fernandez-Gamez and 26 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in aging neuroscience, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06214624 (Effects of Exercise on Brain Health in Patients With Coronary Heart Disease), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06214624 nacompletednot on this map

Effects of Exercise on Brain Health in Patients With Coronary Heart Disease: the Heart-Brain Randomized Controlled Trial

TypeinterventionalSponsorUniversidad de GranadaRan2022 to 2024Enrolled96ConditionsCoronary Heart DiseaseArmsTwo types of exercise interventions
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

36 authors.

Angel TovalDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Patricio Solis-UrraDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Esmée A BakkerDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Lucía Sánchez-ArandaDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Javier Fernández-OrtegaDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Carlos PrietoDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Rosa María Alonso-CuencaDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Alberto González-GarcíaDepartment of Nursing, Faculty of Health Sciences, University of Granada, Granada, Spain.
Isabel Martín-FuentesDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Beatriz Fernandez-GamezDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Marcos Olvera-RojasDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Andrea Coca-PulidoDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Darío BellónDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Alessandro SclafaniDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Javier Sanchez-MartinezDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Ricardo Rivera-LópezCardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain.
Norberto Herrera-GómezDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Rafael Peñafiel-BurkhardtCardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain.
Víctor López-EspinosaCardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain.
Sara Corpas-PérezCardiology Service, San Cecilio Clinical University Hospital, Granada, Spain.
María Belén García-OrtegaCardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain.
Alejandro Vega-CordobaCardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain.
Emilio J Barranco-MorenoDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Francisco J Morales-NavarroDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Raúl NievesDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Alfredo Caro-RusDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Francisco J Amaro-GaheteDepartment of Physiology, Faculty of Medicine, University of Granada, Granada, Spain.
Jose Mora-GonzalezDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Sol Vidal-AlmelaDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Anna CarlénDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Jairo H MiguelesDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Kirk I EricksonAdventHealth Research Institute, Neuroscience, Orlando, FL, United States.
Eduardo Moreno-EscobarCardiology Service, San Cecilio Clinical University Hospital, Granada, Spain.
Rocío García-OrtaCardiology Service, Virgen de Las Nieves University Hospital, Granada, Spain.
Irene Esteban-CornejoDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.
Francisco B OrtegaDepartment of Physical and Sports Education, Sport and Health University Research Institute (iMUDS), Faculty of Sport Sciences, University of Granada, Granada, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Patients with coronary artery disease (CAD) have a higher risk of developing cognitive impairment and mental health disorders compared to the general population. Physical exercise might improve their brain health. The overall goal of the HEART-BRAIN randomized controlled trial (RCT) is to investigate the effects of different types of exercise on brain health outcomes in patients with CAD, and the underlying mechanisms. Methods: This three-arm, single-blinded RCT will include 90 patients with CAD (50-75 years). Participants will be randomized into: (1) control group-usual care ( Conclusion: The HEART-BRAIN RCT will provide novel insights on how exercise can impact brain health in patients with CAD and the potential mechanisms explaining the heart-brain connection, such as changes in cerebral blood flow. The results may have important clinical implications by increasing the evidence on the effectiveness of exercise-based strategies to delay cognitive decline in this high-risk population. Clinical trial registration: ClinicalTrials.gov, identifier [NCT06214624].

Indexed as

cerebral blood flowcognitioncoronary heart diseaseexecutive functionfitnessHIITischemic diseaseresistance training (RT)

Identifiers

PMID39246594
PMCPMC11377337

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.