SynthesisTransplant international : official journal of the European Society for Organ Transplantation2024
Normothermic Regional Perfusion in Controlled Donation After Circulatory Death Liver Transplantation: A Systematic Review and Meta-Analysis.
Synthesis in Transplant international : official journal of the European Society for Organ Transplantation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Normothermic regional perfusion in controlled donation after circulatory death liver transplantation: an updated systematic review and meta-analysis versus non-NRP and brain-death donors.Transplant international : official journal of the European Society for Organ Transplantation · 2026Pooled it
- The Association of Flavin Mononucleotide and Lactate During Normothermic Regional Perfusion with Post-Transplant Liver Outcomes: An Exploratory Study.Medicina (Kaunas, Lithuania) · 2026Article
- Normothermic Regional Perfusion in Controlled Donation After Circulatory Death and its Impact on Postreperfusion Syndrome in Liver Transplantation Compared With Brain-dead Donors: A Retrospective Comparative Study.Transplantation direct · 2026Article
- Advances in the postoperative care of the liver transplant recipient.Current opinion in critical care · 2026Review
- Abdominal normothermic regional perfusion is associated with improved graft survival in liver transplantation from circulatory death donors.Transplant international : official journal of the European Society for Organ Transplantation · 2026Observational
- Implementation of a controlled DCD program in Western Austria - key considerations and insights.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Normothermic regional perfusion (NRP) use in controlled donation after circulatory determination of death (cDCDD): results of the European Society for Organ Transplantation Bucharest consensus conference.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Review
- Thoracoabdominal Normothermic Regional Perfusion Attenuates the Protective Effect of Hypothermic Machine Perfusion on Delayed Graft Function in DCD Kidney Transplantation.Journal of transplantation · 2026Article
- Early and Mid-Term Results of Solid Organ Transplantation After Circulatory Death: A 4-Year Single Centre Experience.Medicina (Kaunas, Lithuania) · 2025Article
- The Impact of Ischaemic Type Biliary Lesions on Healthcare Costs After Liver Transplantation With Grafts From Donors After Circulatory Death.Transplant international : official journal of the European Society for Organ Transplantation · 2025Article
- Liver transplantation from donors following medical assistance in dying: a scoping review and retrospective cohort study.Canadian journal of surgery. Journal canadien de chirurgieArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Liver grafts from controlled donation after circulatory death (cDCD) donors have lower utilization rates due to inferior graft and patient survival rates, largely attributable to the increased incidence of ischemic cholangiopathy, when compared with grafts from brain dead donors (DBD). Normothermic regional perfusion (NRP) may improve the quality of cDCD livers to allow for expansion of the donor pool, helping to alleviate the shortage of transplantable grafts. A systematic review and metanalysis was conducted comparing NRP cDCD livers with both non-NRP cDCD livers and DBD livers. In comparison to non-NRP cDCD outcomes, NRP cDCD grafts had lower rates of ischemic cholangiopathy [RR = 0.23, 95% CI (0.11, 0.49), p = 0.0002], primary non-function [RR = 0.51, 95% CI (0.27, 0.97), p = 0.04], and recipient death [HR = 0.5, 95% CI (0.36, 0.69), p < 0.0001]. There was no difference in outcomes between NRP cDCD donation compared to DBD liver donation. In conclusion, NRP improved the quality of cDCD livers compared to their non-NRP counterparts. NRP cDCD livers had similar outcomes to DBD grafts. This provides further evidence supporting the continued use of NRP in cDCD liver transplantation and offers weight to proposals for its more widespread adoption.
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