ArticleACS omega2024
Selective Naked-Eye Detection of Lung Squamous Cell Carcinoma Mediated by lncRNA SOX2OT Targeted Nanoplasmonic Probe.
Article in ACS omega, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- The interaction between ΔNp63α and TAp63α, mediated by miR-205-5p, inhibits the migration of lung adenocarcinoma cells.Scientific reports · 2025Article
- The emerging role of long non-coding RNA SOX2-OT in cancers and non-malignant diseases.Journal of physiology and biochemistry · 2025Review
- The Emerging Role of Long Non-coding RNA 01296 in Human Malignancies.Current molecular medicine · 2025Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The application of nanobiotechnology in biomolecule detection can provide fast and accurate tests for diagnosing molecular changing-associated diseases. The use of AuNPs-thiolated probe conjugates has long been considered as an alternative method for the detection of specific DNA/RNA targets. Here, we present a colorimetric direct detection method for the SOX2OT transcript, long noncoding RNAs (lncRNAs), by using a poly guanine tail (G12) as a template for in situ synthesis of gold nanoparticles (AuNPs) without any chemical modification or DNA labeling. We have then developed this proposed detection system based on two complementary sequences of long noncoding RNA SOX2OT with an extra strand of poly G12. Using this method, we were able to differentiate lung squamous cell carcinoma from adenocarcinoma samples. Based on this disclosure, this invention provides a simple visual method to detect specific lncRNA sequences without the need for amplifying the target lncRNA and discriminate squamous cell carcinoma from adenocarcinoma samples. Our invention provides a diagnostic kit to detect RNA by means of direct detection (PCR-free) of the lncRNA by in situ synthesis of AuNPs based on two probes with an extra strand of poly G12.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.